越婢汤颗粒剂质量标准研究

Study on the Quality Standard of Yuebi Granules

目的:建立越婢汤颗粒剂的质量标准。方法:对越婢汤颗粒剂中麻黄、生姜、甘草进行了薄层色谱鉴别实验,测定君药麻黄中有效成分盐酸麻黄碱、盐酸伪麻黄碱的含量。结果:盐酸麻黄碱在0.1728~0.5180μg范围内呈良好的线性关系,r=0.9998,平均加样回收率为97.69%,RSD为0.94%;盐酸伪麻黄碱在0.0816~0.2448μg范围内呈良好的线性关系,r=0.999,平均加样回收率为97.06%,RSD为1.02%。结论:该方法可以有效的控制越婢汤颗粒剂的质量。

Objective： To establish the quality standard of Yueyu decoction granules. Methods： Thin-layer chromatography was used to identify Ephedra, Ginger and Glycyrrhiza uralensis in Granules of Yueyu Decoction. The contents of ephedrine hydrochloride and pseudoephedrine hydrochloride in Ephedrae were determined. Results： The ephedrine hydrochloride showed good linearity in the range of 0.1728-0.5180μg, r=0.9998, the average recovery was 97.69%, the RSD was 0.94%, and the pseudoephedrine hydrochloride showed good linearity in the range of 0.0816-0.2448μg. r=-0.999, the average recovery rate was 97.06%, and the RSD was 1.02%. Conclusion： This method can effectively control the quality of Yueyu Tang granules.