单颗粒-电感耦合等离子体质谱测定金纳米颗粒

Effect of Data Acquisition Parameters on Characterization of Gold Nanoparticles By Single Particle Inductively Coupled Plasma-Mass Spectrometry

单颗粒-电感耦合等离子体质谱法(Single particle-inductively coupled plasma-mass spectrometry,SPICP-MS)是近年出现的一种纳米材料分析方法,可用于表征纳米材料的元素组成、粒径分布以及颗粒物浓度。本研究对比了驻留时间(Dwell time,t_d)和稳定时间(Settling time,t_s)等质谱参数对单颗粒分析结果的影响,分析了金纳米颗粒标准物质(NIST 8012,NIST 8013,GBWE 120127)。结果表明,使用短的驻留时间(0.05 ms)和稳定时间(0 ms),可以获得更高的信噪比,检测到更多的纳米颗粒。利用本方法分析了AuNP标准物质,得到的粒径结果与标准值相符。本方法对金纳米颗粒的数量检出限为1.1×10~5L^(-1),粒径检出限为8 nm。

Single particle inductively coupled plasma mass spectrometry（ SP-ICP-MS） is a new tool that can provide the element composition,size distribution,and number concentration of nanoparticles. Here we discussed the effects of dwell time and settling time on analysis of nanoparticles by SP-ICP-MS. We analyzed standard materials of gold nanoparticles（ 30,40 and 60 nm Au NPs,from NIST and NCNST）,showing that better signal-to-noise ratio and higher determination efficiency could be achived when using shorter dwell time and settling time. We utilized a nano mode for SP-ICP-MS,in which the dwell time was set as 0.05 ms and the settling time was 0. The size of NIST Au NP standard material determined here was in accord with the certified size using the developed method. The detection limits of size and number concentration of Au NPs were 8 nm and 1.1×10~5 particle/L,respectively.