重症肌无力伴呼吸衰竭患者并发肺部感染危险因素分析

Study on the Risk Factors of Pulmonary Infection in Patients with Myasthenia Gravis and Respiratory Failure

目的探讨重症肌无力伴呼吸衰竭患者并发肺部感染的危险因素,为预防和治疗提供参考。方法回顾性分析178例重症肌无力伴呼吸衰竭患者的临床资料,统计分析并发肺部感染情况及相关危险因素。结果 178例重症肌无力伴呼吸衰竭患者27例并发肺部感染,感染率为15.2%。男女患者发生肺部感染率比较差异无统计学意义(P>0.05);年龄、住院时间、意识障碍、侵入性操作、呼吸机使用、吸烟史、吞咽困难、合并糖尿病、合并高血压均与重症肌无力伴呼吸衰竭患者发生肺部感染有关系,差异有统计学意义(P<0.05)。结论重症肌无力伴呼吸衰竭患者易并发肺部感染,年龄、住院时间、意识障碍、侵入性操作、吞咽困难、呼吸机使用等均是重症肌无力伴呼吸衰竭并发肺部感染的危险因素,应引起临床重视。

Objective To investigate the myasthenia gravis patients with respiratory failure complicated by lung infection risk factors,and to provide a reference for the prevention and treatment of lung infections. Methods The clinical data of the 178 cases of myasthenia gravis with respiratory failure were analyzed. The situation and related risk factors of pulmonary infection were analyzed statistically.Results The 178 cases of respiratory failure with myasthenia gravis 27 cases was with pulmonary infection. The infection rate was 15. 2%. While gender and myasthenia gravis patients with respiratory failure unrelated to lung infection,the data showed no significant difference（ P 〉 0. 05） comparing manpatients and womanpatients. The age, length of stay, unconsciousness, invasive procedures,ventilator use, smoking history, difficulty swallowing, diabetes, hypertension were associated with respiratory failure in patients with myasthenia gravis lung infections,and the data had statistically significant differences（ P 〈 0. 05）. Conclusion Myasthenia gravis patients with respiratory failure are prone to lung infection. The age, length of stay, unconsciousness, invasive procedures, difficulty swallowing,breathing machine with myasthenia gravis are risk factors for respiratory failure complicated by lung infection. Clinical attention should be paid.