小剂量氨磺必利+度洛西汀在难治性抑郁症治疗中的应用

Application of Low Dose Amisulpride and Duloxetine in the Treatment of Refractory Depression

目的对小剂量氨磺必利联合度洛西汀治疗难治性抑郁症的临床疗效进行探讨分析。方法将我院自2015年8月—2017年8月收治的难治性抑郁症患者98例作为研究对象,将其随机分成实验组(度洛西汀联合氨磺必利治疗)和对照组(单用度洛西汀治疗),每组各49例。采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、不良反应发生情况对患者进行临床疗效评价。结果所研究患者的HAMA评分、HAMD评分均明显降低,但实验组患者治疗1周、2周、4周后HAMA、HAMD评分低于对照组患者,差异具有统计学意义(P<0.05);实验组患者的临床总有效率优于对照组,组间对比,差异具有统计学意义(P<0.05);两组患者不良反应发生情况对比,差异不具有统计学意义(P>0.05)。结论小剂量氨磺必利联合度洛西汀治疗难治性抑郁症较单用度洛西汀疗效更好,没有增加不良反应发生率,安全性好。

Objective To investigate the clinical effect of low dose ammosulpiride combined with doloxetine in the treatment of refractory depression. Methods 98 patients with refractory depression treated in our hospital from August 2015 to August 2017 were selected as the research subjects. They were randomly divided into experimental group（duloxetine combined with amisulpride therapy） and control group（single dose of duloxetine）, 49 cases in each group. Hamilton Depression Scale（HAMD）, Hamilton Anxiety Scale（HAMA） and adverse reactions were used to evaluate the clinical efficacy of the patients. Results The HAMA score and HAMD score of the patients in the study decreased significantly. However, the scores of HAMA and HAMD in the experimental group were lower than those in the control group at 1 week, 2 weeks, and 4 weeks, the difference between the two groups was statistically significant（P〈0.05）. The total clinical effective rate of the experimental group was better than that of the control group, and the difference between the two groups was statistically significant（P〈 0.05）. There was no significant difference in the incidence of adverse reactions between the two groups（P 〈0.05）. Conclusion Low dose ampicillin combined with doloxetine is more effective than duloxetine in the treatment of refractory depression without increasing the incidence of adverse reactions.