腹腔镜术后联合戈舍瑞林治疗巧克力囊肿的效果

Effect of Goserelin combined after laparoscopic surgery treating chocolate cyst

目的比较巧克力囊肿患者腹腔镜术后联合孕三烯酮与戈舍瑞林治疗的临床效果。方法将我院2014年1月~2015年11月收治的72例巧克力囊肿患者作为观察对象,依照随机数字表法分为对照组(n=36)和观察组(n=36)。两组均给予腹腔镜术治疗,在此基础上,对照组加用孕三烯酮,观察组加用戈舍瑞林,对两组患者体内激素水平、临床疗效、妊娠率进行比较。结果在激素水平方面,两组治疗后血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)水平显著降低(P<0.05),但组间血清FSH、LH水平比较差异无统计学意义(P>0.05),而观察组血清E2水平显著低于对照组(P<0.05)。在总有效率、妊娠率方面,观察组者均高于对照组,分别为83.3%vs.61.1%、63.9%vs.38.9%,组间比较差异有统计学意义(P<0.05)。结论巧克力囊肿患者腹腔镜术后联合戈舍瑞林临床效果更加显著,不仅可降低患者激素水平,还可提高妊娠率,值得临床进一步应用与借鉴。

Objective To compare the clinical effect of laparoscopic surgery in patients with chocolate cyst combined with Gestrinone and Goserelin treatment.Methods 72 patients with chocolate cyst treated in our hospital from January2014 to November 2015 were selected as observation subjects and divided into control group（n =36） and observation group（n=36） according to random number table method.Both groups were given laparoscopic treatment.On this basis,the patients in the control group were given Gestrinone and the patients in the observation group were given Goserelin.The levels of hormone,clinical efficacy and pregnancy rate in both groups were statistically analyzed.Results In hormone levels,two groups of after treatment,serum follicle stimulating hormone（FSH）,luteinizing hormone（LH）,estradiol（E2）level were significantly decreased（P〈0.05）,but the groups of serum FSH,there was no significant difference between the level of LH（P〈0.05）,and the serum E2 level of observation group was significantly lower than the control group（P〈0.05）.In terms of the total effective rate,pregnancy rate,the observation group were higher than that in the control group,the data were 83.3% vs. 61.1%,63.9% vs.38.9%,there was a significant difference between groups（P〈0.05）.Conclusion The clinical effect of Goserelin for chocolate cyst patients after laparoscopic surgery is more significant,not only can reduce the hormone level of patients but also can improve the pregnancy rate,which is worthy of further application and clinical reference.