急性冠脉综合征患者血清游离脂肪酸含量与脂代谢紊乱、炎症反应激活的相关性

The correlation of serum free fatty acid content with lipid metabolism disorder and inflammatory response activation in patients with acute coronary syndrome

目的:研究急性冠脉综合征患者血清游离脂肪酸含量与脂代谢紊乱、炎症反应激活的相关性。方法:选择诊断为急性冠脉综合征的患者作为研究的ACS组、同期诊断为稳定型心绞痛的患者作为SAP组、体检的志愿者作为对照组。采集血清并测定游离脂肪酸、脂代谢指标、炎症反应指标、脂肪细胞因子的含量。结果:ACS组、SAP组血清中游离脂肪酸、LDL-C、PCSK9、ApoB、IL-6、IL-17、Chemerin、Visfatin的含量均高于对照组,HDL-C、ApoA1、ApoA5、IL10、sFGL2、TGFβ1、SFRP5、Omentin-1、Vaspin的含量低于对照组;ACS组血清中游离脂肪酸、LDL-C、PCSK9、ApoB、IL-6、IL-17、Chemerin、Visfatin的含量均高于SAP组,HDL-C、ApoA1、ApoA5、IL10、sFGL2、TGFβ1、SFRP5、Omentin-1、Vaspin的含量低于SAP组。结论:急性冠脉综合征患者血清中游离脂肪酸的升高与脂代谢紊乱、炎症反应激活密切相关。

Objective：To study the correlation of serum free fatty acid content with lipid metabolism disorder and inflammatory response activation in patients with acute coronary syndrome.Methods：Patients who were diagnosed with acute coronary syndrome in Zigong First People＇s Hospital between March 2015 and April 2017 were chosen as the ACS group of the research,patients who were diagnosed with stable angina pectoris during the same period were chosen as the SAP group and the volunteers who accepted physical examination during the same period were chosen as the control group.Serum was collected to determine the levels of free fatty acid,lipid metabolism indexes,inflammatory response indexes and adipocytokines.Results：Serum free fatty acid,LDL-C,PCSK9,ApoB,IL-6,IL-17,Chemerin and Visfatin levels of ACS group and SAP group were higher than those of control group whereas HDL-C,ApoA1,ApoA5,IL10,sFGL2,TGFβ1,SFRP5,Omentin-1 and Vaspin levels were lower than those of control group（P 0.05）;serum free fatty acid,LDL-C,PCSK9,ApoB,IL-6,IL-17,Chemerin and Visfatin levels of ACS group were higher than those of SAP group whereas HDL-C,ApoA1,ApoA5,IL10,sFGL2,TGFβ1,SFRP5,Omentin-1 and Vaspin levels were lower than those of SAP group（P0.05）.Conclusion：The increase of free fatty acid in serum of patients with acute coronary syndrome is closely related to the lipid metabolism disorder and inflammatory response activation.