慢性心衰患者血清Ang-2含量与神经体液指标、心肌重构指标的相关性研究

The correlation of serum Ang-2 level with neurohumor indexes and myocardial remodeling indexes in patients with chronic heart failure

目的:研究慢性心衰患者血清血管生成素2(Ang-2)含量与神经体液指标、心肌重构指标的相关性。方法:选择黄梅县人民医院2015年3月~2017年10月期间收治的慢性心衰患者,根据心功能分级分为NYHA I-II组、NYHA III-IV组;另取同期体检的健康者作为对照组。测定血清中Ang-2、神经体液指标、心肌重构指标的含量。结果:NYHA I-II组、NYHA III-IV组患者血清中Ang-2、NT-proBNP、Copeptin、ET-1、AT-II、ALD、FGF23、TGFβ1、Gal-3、PICP、ICTP的含量显著高于对照组,TIMP4的含量显著低于对照组;NYHA III-IV组患者血清中Ang-2、NT-proBNP、Copeptin、ET-1、AT-II、ALD、FGF23、TGFβ1、Gal-3、PICP、ICTP的含量显著高于NYHA I-II组患者,TIMP4的含量显著低于NYHA I-II组患者。Ang-2高含量的慢性心衰患者血清中NT-proBNP、Copeptin、ET-1、AT-II、ALD、FGF23、TGFβ1、Gal-3、PICP、ICTP的含量显著高于Ang-2低含量的慢性心衰患者,TIMP4的含量显著低于Ang-2低含量的慢性心衰患者。结论:慢性心衰患者血清Ang-2含量的升高与神经体液紊乱、心肌重构加剧有关。

Objective：To study the correlation of serum angiogenin 2（Ang-2）level with neurohumor indexes and myocardial remodeling indexes in patients with chronic heart failure.Methods：The patients with chronic heart failure who were treated in the People＇s Hospital of Huangmei between March 2015 and October 2017 were selected and divided into NYHA III group and NYHA III-IV group according to cardiac function classification;healthy subjects who received physical examination during the same period were selected as the control group.The levels of Ang-2,neurohumor indexes and myocardial remodeling indexes in serum were determined.Results：Serum Ang-2,NT-proBNP,Copeptin,ET-1,AT-II,ALD,FGF23,TGFβ1,Gal-3,PICP and ICTP levels of NYHA I-II group and NYHA III-IV group were significantly higher than those of control group whereas TIMP4 levels were significantly lower than that of control group;serum Ang-2,NT-proBNP,Copeptin,ET-1,AT-II,ALD,FGF23,TGFβ1,Gal-3,PICP and ICTP levels of NYHA III-IV group were significantly higher than those of NYHA I-II group whereas TIMP4 level was significantly lower than that of NYHA I-II group.Serum NT-proBNP,Copeptin,ET-1,AT-II,ALD,FGF23,TGFβ1,Gal-3,PICP and ICTP levels in chronic heart failure patients with high Ang-2 level were significantly higher than those in chronic heart failure patients with low Ang-2 level whereas TIMP4 level was significantly lower than that in chronic heart failure patients with low Ang-2 level.Conclusion：The increase of Ang-2 in patients with chronic heart failure is related to neurohumoral disorder and myocardial remodeling aggravation.