超声肿瘤体积倍增时间(TVDT)与乳腺癌病灶内恶性分子表达的相关性

Correlation between ultrasonic tumor volume doubling time and malignant molecule expression in breast cancer

目的:探讨超声肿瘤体积倍增时间(TVDT)与乳腺癌病灶内恶性分子表达的相关性。方法:2016年8月~2017年8月间在本院接受手术治疗的乳腺癌患者118例作为乳腺癌组,同期在本院进行腺瘤切除术的乳腺腺瘤患者100例作为乳腺腺瘤组。对比两组患者的病灶组织TVDT水平,增殖相关基因、侵袭相关基因mRNA表达量的差异。采用Pearson检验评估乳腺癌患者超声TVDT水平与肿瘤恶性分子表达量的内在联系。结果:乳腺癌组患者肿瘤TVDT水平低于乳腺腺瘤组患者;乳腺癌组患者肿瘤组织中促增殖基因PKM2、Notch1、FSCN1 mRNA的表达量高于乳腺腺瘤组,抗增殖基因FBXW7、HSG、EBP50mRNA的表达量低于乳腺腺瘤组;乳腺癌组患者肿瘤组织中促侵袭基因Gab2、VEGF mRNA的表达量高于乳腺腺瘤组,抗侵袭基因NDRG1、DKK-1、NUAK1 mRNA的表达量低于乳腺腺瘤组。Pearson检验发现,乳腺癌病灶TVDT水平与增殖相关基因、侵袭相关基因表达量均直接相关。结论:乳腺癌病灶超声TVDT水平异常降低,具体TVDT水平与肿瘤细胞增殖、侵袭活性直接相关。

Objective：To investigate the correlation between ultrasonic tumor volume doubling time（TVDT）and malignant molecule expression in breast cancer.Methods：118 patients with breast cancer undergoing surgical treatment in this hospital between August 2016 and August 2017 were selected as breast cancer group and 100 patients with breast adenoma undergoing adenoma resection in this hospital during the same period were selected as breast adenoma group.The differences in TVDT levels as well as proliferation-related gene and invasion-related gene mRNA expression in lesion tissue were compared between the two groups of patients.Pearson test was used to assess the intrinsic relationship between ultrasonic TVDT level in patients with breast cancer and malignant molecule expression in tumor.Results：The tumor TVDT level of breast cancer group was lower than that of breast adenoma group;pro-proliferation genes PKM2,Notch1 and FSCN1 mRNA expression in tumor tissue of breast cancer group were higher than those of breast adenoma group whereas anti-proliferation genes FBXW7,HSG and EBP50 mRNA expression were lower than those of breast adenoma group;pro-invasion genes Gab2 and VEGF mRNA expression in tumor tissue of breast cancer group were higher than those of breast adenoma group whereas anti-invasion genes NDRG1,DKK-1 and NUAK1 mRNA expression were lower than those of breast adenomagroup.The Pearson test showed that the TVDT level of breast cancer was directly correlated with the expression of proliferation-related genes and invasion-related genes.Conclusion：Ultrasonic TVDT level of breast cancer decreases abnormally,and the specific TVDT level is directly correlated with tumor cell proliferation and invasion activity.