二甲基砜对小鼠抗炎作用及免疫功能的影响

Effect of dimethyl sulfone on anti-inflammatory and immune function in mice

目的:考察二甲基砜对脂多糖(LPS)诱导的炎症小鼠血清中的细胞因子的影响及碳廓清能力,探索二甲基砜的抗炎作用和对免疫功能的影响。方法:将小鼠随机分为空白对照组、模型对照组、地塞米松阳性组及二甲基砜高、中、低剂量组,连续给药7天后,腹腔注射LPS,采血后检测血清中IL-17F、IL-22、IL-23、TNF-α表达水平,并计算各组小鼠的脾脏、胸腺系数及单核-巨噬细胞的碳廓清能力。结果:与模型组比较,二甲基砜组能明显减少促炎因子IL-17F、TNF-α的分泌,并增强抗炎因子IL-22的表达水平,显著提高巨噬细胞吞噬率。结论:二甲基砜对LPS诱导的炎症小鼠具有明显的抗炎作用,增强小鼠免疫功能,且其对免疫系统无明显抑制作用。

Objective： To investigate the effects of dimethyl sulfone on serum cytokines in mice induced by lipopolysaccharide （LPS） and the ability of carbon clearance, To explore the anti-inflammatory effect of dimethyl sulfone and its effect on immune function. Methods： The mice were randomly divided into blank control group, model control group, dexamethasone positive group and dimethylsulfone high, medium and low dose groups. After continuous administration for 7 days, LPS was injected intraperitoneally, Testing the IL -17F, IL-22, IL-23 and TNF-α of serum, Calculate the spleen, thymus coefficient and the ability of carbon monocyte-macrophage carbon clearance in each group. Results： Compared with the model group, dimethyl sulfone group could significantly reduce the secretion of proinflammatory cytokines IL-17F and TNF-α, enhance the expression of anti-inflammatory factor IL-22 and significantly increase the phagocytosis rate of macrophages. Conclusion： Dimethyl sulfone has obvious anti-inflammatory effect on LPS-induced inflammatory mice and enhances immune function in mice, and it has no obvious inhibitory effect on immune system.