普米克令舒对重症肺炎支原体肺炎患儿肺功能的影响

Effect of Pulmicort respulas on lung function of children with severe Mycoplasma pneumoniae pneumonia

目的探讨普米克令舒对重症肺炎支原体肺炎患儿肺功能的影响。方法选择2015年10月至2017年2月本院小儿急诊科收治的50例重症肺炎支原体肺炎患儿,随机分为试验组(25例)和对照组(25例),对照组采用阿奇霉素+对症治疗,试验组在对照组治疗基础上加用普米克令舒,两组疗均为5 d。比较2组受试者肺功能、疾病疗效及临床症状体征消失时间。结果肺功能各项指标治疗前后的变化值:试验组PEF、FEV1、FEV1/FVC、V75、V50、V25分别为(16.27±3.03)%、(14.24±2.23)%、(9.53±1.75)%、(9.51±1.30)%、(18.53±3.67)%、(17.15±5.37)%,对照组分别为(13.57±2.63)%、(10.52±2.53)%、(7.62±1.32)%、(6.75±1.34)%、(14.37±4.37)%、(11.20±8.52)%,两组比较差异均有统计学意义(P<0.05);住院时间及症状体征消失时间:试验组住院时间、胸片转阴时间、咳嗽消失时间、啰音消失时间、发热消退时间分别为(6.02±2.62)d、(5.12±2.32)d、(4.26±3.91)d、(3.20±2.91)d、(3.23±2.07)d,对照组分别为(7.82±3.09)d、(6.62±1.97)d、(6.72±4.20)d、(4.91±3.07)d、(5.17±2.91)d,两组比较差异均有统计学意义(P<0.05);疾病疗效:试验组总有效率为92.00%,对照组总有效率为72.00%,两组比较差异均有统计学意义(P<0.05)。结论短时间合用普米克令舒治疗重症肺炎支原体肺炎,能明显缩短疗程、改善肺功能、提高疾病疗效。

Objective To evaluate the effect of Pulmicort respulas on lung function of the children with severe Mycoplasma pneumoniae pneumonia（MPP）. Methods 50 children admitted in the Emergency Medicine of Pediatrics,Qingdao Women and Children＇ s Hospital from October 2015 to February 2017 were divided into treatment group（25 cases） and control group（25 cases）. Patients in the control group were treated by azithromycin and symptomatic treatment,and those in the treatment group were treated with Pulmicort respulas in addition to the treatment given in the control group. The course of treatment was 5 days. The lung function,therapeutic effect and the disappearance time of clinical symptoms and signs between the two groups were compared before and after treatment. Results The change values of various indexes of lung function before and after treatment,i.e. PEF,FEV1,FEV1/FVC,V75,V50,V25 in the treatment group were（16.27±3.03） %,（14. 24 ± 2. 23） %,（9. 53 ± 1. 75） %,（9. 51 ± 1. 30） %,（18. 53 ± 3. 67） %,（17. 15 ± 5. 37） %respectively,and（13.57±2.63） %,（10.52±2.53） %,（7.62± 1.32） %,（6.75± 1.34） %,（14.37± 4.37） %,（11.20± 8.52） % respectively in the control group. The hospital stay and the disappearance time of clinical symptoms and signs,the time for negative signs on X-ray,cough disappearance,rale disappearance and fever subsidence in the treatment group were（6.02±2.62） days,（5.12± 2.32） days,（4.26± 3.91） days,（3.20±2.91） days and（3.23±2.07） days respectively;（7.82±3.09） days,（6.62±1.97） days,（6.72±4.20） days,（4.91± 3.07） days and（5.17± 2.91） days respectively in the control group. The total effective rate of the treatment group was 92.00%,and that of the control group was 72.00%.All above indexes showed statistical differences between the two groups（P〈0.05）.ConclusionRoutine treatment plus a short time of Pulmicort respulas administration could shorten the treatment course,improve lung function and ameliorate the therapeutic effect of severe MPP.