重度子痫前期预测指标的研究

Study on the predictor for severe preeclampsia

目的探讨联合检测D-二聚体(D-Dimer,D-D)、C反应蛋白(C-reactive protein,CRP)和游离雌三醇(unconjugated estriol,uE3)对重度子痫前期的预测价值。方法选取2016-01—2017-09濮阳市妇幼保健院就诊的子痫前期患者,A组:子痫前期患者40例,B组:重度子痫前期患者40例,C组:与之匹配的正常孕妇40例。观察3组患者血D-D、CRP和uE_3水平。结果血清CRP水平A、B组均显著高于C组,且B组高于A组(P<0.01);血浆D-D水平A、B组均显著高于C组,且B组高于A组(P<0.01);血清uE3水平B组显著低于A组、C组(P<0.01),A组与C组无显著性差异。结论联合检测D-D、CRP和uE3可以提高重度子痫前期预测的敏感性和特异性。

Objective To discuss the predictive value of combined detection of D-Dimer（D-D）,C-reactive protein（CRP） and unconjugated estriol（uE3） for severe preeclampsia.Methods We set three groups in this study：group A：40 cases of preeclampsia;group B：40 cases of severe preeclampsia;group C：40 cases as matching control.We analyzed the level of plasma DD,serum CRP and uE3in the three groups.Results The levels of plasma D-D and serum CRP in preeclampsia patients were increased,the changes in patients of severe preeclampsia were moresignificant（P 〈0.01）.The levels of serum uE3 in severe preeclampsia patients were lower（P 〈0.01）.Conclusions Combined detection of D-Dimer（D-D）,C-reactive protein（CRP） and unconjugated estriol（uE3） has higher sensitivity and specificity of the predictive value for severe preeclampsia.