硝苯地平和酚妥拉明联合硫酸镁对妊娠高血压综合征患者BNP的影响

Effects of combination of nifedipine,phentolamine and magnesium sulfate on brain natriuretic peptide in patients with pregnancy induced hypertension syndrome

目的通过对临床妊娠高血压综合征(妊高征)患者给予实施硝苯地平、硫酸镁以及酚妥拉明三药联合治疗,观察对患者血清血浆脑钠肽(BNP)含量的影响,探讨三药联合应用对保护妊娠高征患者心脏功能的治疗价值。方法选取2015年4月至2017年2月就诊的妊高征患者,根据自愿参与原则,利用随机数字表法将108例患者分为研究组和对照组1、对照组2,每组36例。研究组给以硝苯地平、硫酸镁及酚妥拉明三药联合治疗,而对照组1给以硝苯地平和硫酸镁治疗,对照组2给以酚妥拉明和硫酸镁治疗,分析研究组与对照组1和对照组2治疗过程中血清BNP含量的变化,对治疗前后组间数值分析对比。结果研究组与对照组1进行比较,治疗前后2组血清BNP含量均下降,差异有统计学意义(P<0.05);治疗后研究组下降更显著,与治疗前比较差异无统计学意义(P>0.05),而治疗后2组差异有统计学意义(P<0.05);研究组与对照组2比较,治疗前后2组血清BNP含量均有下降,差异有统计学意义(P<0.05);治疗后研究组下降更显著,与治疗前差异无统计学意义(P>0.05),而治疗后2组差异有统计学意义(P<0.05)。结论妊高征患者实施硝苯地平、硫酸镁以及酚妥拉明三药联合治疗时,其降低血清BNP含量的的效果更加可靠,明显优于其他二药的联合应用,说明对保护妊高征患者心脏功能具有可靠的治疗价值。

Objective To investigate the effects of the combination of nifedipine, magnesium sulfate and phentolamine on brain natriuretic peptide（ BNP） levels in plasma and serum of patients with pregnancy induced hypertension syndrome（ PIH）,and to explore the therapeutic value of combination of three drugs in protection effects on cardiac function of patients with PIH. Methods On the basis of the principle of voluntary participation,a total of 108 patients with PIH who were treated in our hospital from April 2015 to February 2017 were enrolled in the study,who were divided into research group（ n = 36）,control group 1（ n = 36） and control group 2（ n = 36） according to a random number table. The patients in research group were treated by combination application of nifedipine,magnesium sulfate and phentolamine,however,the patients in control group 1 were treated by nifedipine and magnesium sulfate,and those in control group 2 were treated by phentolamine and magnesium sulfate. The changes of serum BNP levels during treatment were observed and compared among the three groups. Results The serum levels of BNP were reduced before and after treatment in both research group and control group 1,and there were significant differences between the two groups（ P〈0. 05）,moreover,the decrease degree in research group was more significant than that in control group 1. There were no significant differences in serum levels of BNP in research group after treatment,as compared with those before treatment（ P〈0. 05）,however,there were significant differences after treatment（ P〈0. 05）. In addition the serum levels of BNP were decreased before and after treatment in both research group and control group 2（ P〈0. 05）,moreover the decrease degree in research group after treatment was more significant than that in control group 2,and there were significant differences in serum levels of BNP after treatment between research group and control group 2（ P〈0. 05）. Conclusion The combination application of nifedipine,magnesium sulphate and phentolamine is more reliable in reducing serum levels of BNP of patients with PIH,which is superior to the combination application of the other two drugs,which suggests that combination of three drugs has a reliable value in the protection of cardiac function of patients with PIH.