干扰素调节因子8抑制辅助性T淋巴细胞17分化在白塞病发病机制中的作用

Role of interferon regulatory factor 8 inhibiting helper T cell 17 differentiation in pathogenesis of Beh?et's disease

白塞病是一种主要表现为复发性口腔溃疡、生殖器溃疡、眼炎和皮肤损害的慢性系统性血管炎。白塞病发病机制尚不明确,可能是遗传易感个体在感染或环境等因素触发下发生的自身免疫性疾病,辅助性T淋巴细胞17(Th17)在白塞病发病过程中有重要作用。干扰素调节因子8(IRF8)可抑制Th17分化,从而抑制Th17及白细胞介素17产生的炎性反应。基因组学研究提示,IRF8相关单核苷酸多态性位点是白塞病的风险基因位点。近年来,IRF8抑制Th17分化在白塞病发病机制中的作用已经成为研究热点。

Beh？et＇s disease（BD） is a chronic systemic vasculitis that mainly characterized by recurrent oral ulcers, genital ulcers, uveitis and skin lesions. The pathogenesis of BD is still unknown. BD is considered to be an autoimmune disease triggered by infection or environmental factors in genetically susceptible individuals. Helper T cell 17（Th17） play an important role in the pathogenesis of BD. Interferon regulatory factor 8（IRF8） inhibits Th17 differentiation, thereby inhibiting the inflammation induced by Th17 and interleukin 17. Genomic studies suggest that IRF8-associated single nucleotide polymorphisms（SNPs） are risk loci of BD. In recent years, role of IRF8 inhibiting Th17 differentiation in the pathogenesis of BD has become a research focus.