中西医结合序贯疗法治疗慢性胃炎伴幽门螺杆菌感染疗效观察

Clinical observation of the sequential therapy of traditional Chinese combined with western medicine in the treatment of chronic gastritis complicated with Helicobacter pylori infection

目的:研究中西医结合序贯疗法对幽门螺杆菌(HP)根除的效果。方法:选取60例慢性胃炎伴HP感染病人,随机分为A、B组及对照组,各20例。其中对照组予西药序贯疗法治疗10 d;A组予西药序贯疗法治疗10 d联合中药辨证论治4周;B组予西药序贯疗法治疗10 d联合中药辨证论治2周。观察3组HP根除率,并采用症状积分量表测评。结果:3组病人治疗后症状积分均显著低于治疗前(P<0.01);3组治疗后有效率及HP根除率差异均无统计学意义(P>0.05)。A组和B组不良反应的发生率均低于对照组(P<0.05)。结论:中西医结合序贯疗法治疗慢性胃炎伴HP感染能根除HP,缓解症状,且不良反应发生率有低于单独应用西药序贯疗法的趋势。

Objective： To study the effects of the sequential therapy of traditional Chinese combined with western medicine in the eradication of Helicobacter pylori（ HP） for provoding the reference in treating chronic gastritis complicated with HP infection. Methods：Sixty patients with chronic gastritis complicated with HP infection were randomly divided into the group A,group B and control group（ 20 cases each group）. The control group were treated with the sequential therapy of western medicine for 10 days,the group A were treated with the sequential therapy of western medicine for 10 days,then with traditional Chinese for 4 weeks,and the group B were treated with the sequential therapy of western medicine for 10 days,then with traditional Chinese for 2 weeks. The eradication rates of HP in three groups were observed,which was evaluated using symptom score scale. Results： The symptom scores in three groups after treatment were significnatly lower than those before treatment（ P〈0. 01）. The differences of the eradication rates of HP between three groups were not statistically significant after treatment（ P〉0. 05）. The incidence rates of adverse reactions in group A and group B were lower than that in control group（ P〈0. 05）. Conclusions： The sequential therapy of traditional Chinese combined with western medicine in the treatment of chronic gastritis complicated with HP infection can eradicate the HP and relieve symptoms,and the incidence rate of adverse reaction of which is lower than that of single sequential therapy of western medicine.