地诺前列酮栓与催产素、米索前列醇对妊娠结局的影响

Effect of Dinoprostone Suppositories and Oxytocin, Misoprostol on Pregnancy Outcome

目的探讨地诺前列酮栓与催产素、米索前列醇应用于促宫颈成熟中的效果以及对分娩结局的影响,为临床应用提供参考依据。方法选取我院2015年1月—2017年1月所收治过期妊娠产妇117例,随机分为对照组A、对照组B和研究组。对照组A39例,予以催产素2.5U;对照组B39例,予以米索前列醇25μg;研究组39例,予以地诺前列酮栓10 mg。比较三组促宫颈成熟评分及分娩结局。结果研究组患者中,显效32例、有效4例,其临床总有效率为92.31%,明显优于对照组A的69.23%、对照组B的71.79%,χ~2分别为5.283、4.266,差异具有统计学意义(P<0.05)。研究组引产成功率为87.18%,明显优于对照组A的58.97%、对照组B的64.10%,χ~2分别为6.516、4.453,差异具有统计学意义(P<0.05)。结论地诺前列酮栓可有效促进宫颈成熟,提升引产成功率,有利于保障母婴安全,值得临床推广应用。

Objective To investigate Dinoprostone Suppositories and oxytocin, misoprostol for cervical ripening and the effect of impact on birth outcomes, and provide reference for clinical application. Methods 117 cases of parturients treated in our hospital in January 2015 to January 2017 were randomly divided into the control group A, the control group B and the study group. The control group A39 cases, were given oxytocin 2.5 U; control group of B39 cases, 25 μg misoprostol; 39 cases of the study group, to Dinoprostone Suppositories 10 mg. The three groups were compared to promote the cervical maturity score and the outcome of delivery. ResultsIn the study group, 32 cases were markedly effective and 4 cases were effective. The total effective rate of the study group was 92.31%, which was significantly higher than that of the control group A and 69.23% of the control group and 71.79% of the control group B, χ^2 were 5.283 and 4.266, respectively. The difference was statistically significant（P﹤0.05）. The success rate of induced labor in the study group was 87.18%, which was significantly better than 58.97% in the control group and 64.10% in the control group B, and χ^2 was 6.516 and 4.453, respectively, and the difference was statistically significant（P﹤0.05）. ConclusionDinoprostone Suppositories can effectively promote cervical ripening, improve the success rate, to ensure their safety, it is worthy of clinical application.