前列腺癌ADC值比率与DWI评分的相关性研究

Correlation study on the apparent-diffusion coefficient with diffusion-weighted imaging in prostate cancer by prostate imaging reporting and data system

目的:分析前列腺癌灶ADC值比率与PI-RADS V2中癌灶DWI评分的相关性,并探讨ADC值比率在DWI评分中的应用价值。方法:搜集经病理证实的前列腺癌患者45例,甲、乙两位阅片者独立对前列腺癌灶进行DWI评分,测量ADC值及ADC值比率,分析DWI评分与ADC值、ADC值比率的相关性,ROC分析ADC值比率诊断DWI评分≥4时的曲线下面积(AUC)及其诊断效能。结果:前列腺癌灶ADC值比率与癌灶DWI评分呈正相关(r甲=0.841;r乙=0.788)。甲乙两者ADC值比率判断DWI≥4分时的诊断阈值均>1.4。结论:前列腺癌灶ADC值比率越大,DWI评分越高。ADC值比率可以弥补定性图像分析的不足,提高DWI评分的稳定性并辅助评分。

Objective：To analyze the correlation of the apparent-diffusion coefficient（ADC） with diffusion-weighted imaging（DWI） in prostate cancer by the Prostate Imaging-Reporting and Data System version 2（ PI-RADS V2） for assessing the value of ADC and DWI scoring in diagnosis of prostate cancer.Methods：The images of prostate cancers pathologically confirmed were independently reviewed by two radiologists. The DWI scores on the lesions were documented,and ADC and its ratio to DWI were measured for analysis of the correlation of the two indexes. Receiver operating characteristic（ ROC） curve was used to estimate the diagnostic efficacy for the prostate cancer under the area of the curve（ AUC） at DWI scoring≥4. Results：ADC ratio of prostate cancer was positively correlated with DWI scores（ r = 0. 841; r = 0. 788,respectively by the two radiologists）. The diagnostic threshold value was greater than 1. 4 when using ADC ratio and DWI≥4 by the two radiologists. Conclusion：The bigger of the ADC ratio in prostate cancer is,the higher the DWI scoring will be. The findings suggest that ADC can offset the deficiency of qualitative analysis of the imaging and improve the stability of DWI scoring as well as be an auxiliary tool for DWI scoring.