摘要
目的探索glypican-6基因在鼻咽癌中的表达水平,预测glypican-6参与鼻咽癌发生发展的关系。方法从癌症基因组图谱(the cancer genome atlas,TCGA)提取头颈癌glypican-6的数据进行整合;有临床样本信息的成对(癌和癌旁)RNA-seq数据,通过edgeR分析软件完成分析工作。结果 glypican-6在鼻咽癌组织中的表达水平较癌旁组织显著上调。结论 Glypican-6可作为促癌基因在鼻咽癌中发挥作用,有望成为鼻咽癌的预后指标或者治疗靶点。
Objective To explore the expression level of glypican-6 gene in nasopharyngeal carcinoma and predict the relationship between glypican-6 and development of nasopharyngeal carcinoma.Methods The data of head and neck cancer glypican-6 were extracted from the Cancer Genome Atlas（TCGA）.RNA-seq data of paired（cancer and paracancerous）samples with clinical sample information were analyzed by edgeR analysis software.Results The expression level of glypican-6 in nasopharyngeal carcinoma tissues was significantly higher than that in the paracancerous tissue.Conclusion Glypican-6 can play a role in nasopharyngeal carcinoma as a carcinogenic gene,and is expected to be a prognostic indicator or therapeutic target for nasopharyngeal carcinoma.
作者
倪茂美
杨秀海
刘蕾
聂敏
付珮一
刘世喜
Ni Maomei;Yang Xiuhai;Liu Lei;Nie Min;Fu Peiyi;Liu Shixi(Department of Otorhinolaryngology, Guizhou Provincial People＇s Hospital, Guiyang 550002, Guizhou, China.;Department of Clinical Laboratory, Guizhou Provincial People＇s Hospital, Guiyang 550002, Guizhou, China.;Department of Otorhinolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan China.)
出处
《贵州医药》
CAS
2018年第5期515-517,共3页
Guizhou Medical Journal
基金
贵州省人民医院青年基金[合同编号:GZSYQN(2016)02号]
