神经节苷脂联合长春西汀治疗急性期进展性脑卒中47例疗效观察

Clinical Observation on Monosialotetrahexosylganglioside Sodium Injection Combined with Vinpocetine Injection in the Treatment of 47 Patients with Progressive Stroke in Acute Stage

目的探讨神经节苷脂联合长春西汀治疗急性期进展性脑卒中的临床疗效。方法按照随机数字表法将93例急性期进展性脑卒中患者分为观察组(n=47)和对照组(n=46),对照组患者在常规治疗基础给予单唾液酸四己糖神经节苷脂钠注射液治疗,观察组患者在对照组治疗基础上联合长春西汀注射液治疗,连续治疗2周。结果治疗2周后,两组患者的美国国立卫生研究院卒中量表(NIHSS)评分均低于治疗前,日常生活活动能力量表(ADL)评分高于治疗前,且观察组的NIHSS评分低于对照组,ADL评分高于对照组(P<0.05);观察组临床疗效优于对照组(Z=2.479,P=0.013),观察组总有效率为95.74%,高于对照组的80.43%(χ~2=5.225,P=0.022);治疗2周后,两组患者血清氧化低密度脂蛋白(ox-LDL),超敏C反应蛋白(hs-CRP)水平均低于治疗前,且观察组低于对照组(P<0.05)。结论神经节苷脂联合长春西汀治疗急性期进展性脑卒中疗效显著,能明显降低血清ox-LDL及hs-CRP水平,改善神经功能。

Objective To investigate the clinical effect of Monosialotetrahexosylganglioside Sodium Injection combined with Vinpocetine Injection in the treatment of patients with progressive stroke in acute stage. Methods Totally 93 patients with progressive stroke in acute stage were divided into the observation group（ n = 47） and the control group（ n = 46） according to the random table number method. The control group was treated with Monosialotetrahexosylganglioside Sodium Injection on the basis of conventional treatment,while the observation group was treated with Vinpocetine Injection on the basis of the control group. The two groups were continuously treated for 2 weeks.Results After 2 weeks of treatment,the NIHSS scores of two groups were lower than those before treatment,while ADL scores of two groups were higher than those before treatment,the NIHSS score in the observation group was lower than that in the control group,the ADL score in the observation group was higher than that in the control group（ P〈0. 05）. The clinical efficacy of the observation group was better than that of the control group（ Z = 2. 479, P = 0. 013）. The total effective rate of the observation group was 95. 74%,which was significantly higher than 80. 43% of the control group（ χ~2= 5. 225, P = 0. 022）. After 2 weeks of treatment, the levels of serum ox-LDL,hs-CRP in the two groups were lower than those before treatment,and those in the observation group were lower than those in control group（ P〈0. 05）. Conclusion Monosialotetrahexosylganglioside Sodium Injection combined with Vinpocetine Injection in the treatment of patients with progressive stroke in acute stage has a significant curative effect,it can obviously reduce levels of serum ox-LDL,hs-CRP,and improve the nerve function.