结核分枝杆菌北京基因型与不良治疗结局的研究进展

Research progress ofrelationships between Mycobacterium tuberculosis Beijing genotype and adverse outcomes

感染结核分枝杆菌北京基因型患者与复发、治疗失败等不良结局有着密切的关联,本研究归纳北京基因型与治疗不良结局间的关联。分析北京基因型在蛋白质表达、脂质结构与免疫力方面与其他基因型相比的特别之处,以及由此而导致的毒性增强、免疫逃避与削弱宿主反应能力、推进疾病从潜伏发展为活动性结核等生化特性,并探讨引起北京基因型结核分枝杆菌传播的可能协同影响因素。

Tuberculosis patients infected with the Beijing genotype are closely associated with unfavorable treatment outcomes such as relapse and treatment failure.This study summarized the research progress of relationships between Beijing genotype and poor treatment outcomes through：analysis of Beijing genotype in terms of protein expression,lipid structure and immunity compared to other genotypes;discussion of resulting biochemical characteristics such as increased toxicity,immune evasion and weakening of the host＇s ability to respond and advancement of disease from latent infection to active disease;together with exploration of the possible synergistic influences of Beijing genotype transmission.