降钙素原和C反应蛋白检测在小儿急性呼吸道感染中的临床价值研究

Study on Clinical Value of Procalcitonin and C Reactive Protein Detection in Children with Acute Respiratory Tract Infection

目的探讨降钙素原(PCT)和C反应蛋白(CRP)检测在小儿急性呼吸道感染中的临床价值。方法选取我院2017年4月至2017年12月期间收治的小儿急性呼吸道感染患儿80例,依据患儿的诊断结果分为病毒性感染组(40例)和细菌性感染组(40例),另选取同期体检健康儿童40例作为对照组。检测并分析三组儿童的血清PCT、CRP水平。结果病毒性感染组的CRP、PCT、CRP联合PCT检测阳性率均低于细菌性感染组(P<0.05)。治疗前,细菌性感染组的血清PCT、CRP水平均高于病毒性感染组和对照组(P<0.05)。治疗后,细菌性感染组与病毒性感染组的血清PCT、CRP水平比较均无统计学差异(P>0.05)。结论 PCT、CRP指标可应用于临床诊断小儿急性呼吸道感染,并可用于区分鉴定病毒性感染和细菌性感染,有利于早期诊断呼吸道感染病情,CRP联合PCT检测的临床价值更高。

Objective To explore the clinical value of procalcitonin（PCT） and C reactive protein（CRP） detection in children with acute respiratory tract infection. Methods 80 cases of children with acute respiratory tract infection admitted to our hospital from April 2017 to December 2017 were selected and randomly selected and divided into viral infection group（40 cases） and bacterial infection group（40 cases） according to the diagnostic results. Another 40 healthy children with physical examination at the same time were selected as the control group. The serum PCT and CRP levels of three groups were detected and analyzed. Results The positive rates of CRP, PCT and CRP combined with PCT of the viral infection group were lower than those of the bacterial infection group（P 〈0.05）. Before treatment, the serum CRP and PCT levels of the bacterial infection group were higher than those of the viral infection group and control group（P 〈0.05）. After treatment, no statistical difference was found in the serum PCT and CRP levels between the bacterial infection group and viral infection group（P 〉0.05）. Conclusions PCT and CRP can be used for the clinical diagnosis of children with acute respiratory tract infection, and can be used to distinguish the viral infection and bacterial infection, which is beneficial to early diagnosis of respiratory infection. The combined detection of CRP and PCT has higher clinical value.