TPOAb与TGAb联合检测对桥本甲状腺炎的诊断价值

Diagnostic Value of Combined Detection of TPOAb and TGAb for Hashimoto's Thyroiditis

目的探讨TPOAb(抗甲状腺过氧化物酶抗体)与TGAb(甲状腺球蛋白抗体)联合检测桥本甲状腺炎的临床诊断价值。方法选取我院2016年3月至2017年10月收治的85例桥本甲状腺炎患者作为研究组,另选取同期42例健康体检者作为对照组。检测两组的TPOAb、TGAb,分析单项检测与联合检测的敏感度、特异度。结果研究组的TPOAb、TGAb水平明显高于对照组(P<0.05)。研究组的TPOAb检测的敏感度、特异度分别为92.94%、95.23%,均高于TGAb检测的91.76%、88.09%。TPOAb与TGAb联合检测的敏感度明显高于单项检测(P<0.05)。结论 TPOAb、TGAb联合检测能够提高桥本甲状腺炎的诊断率,有助于尽早发现疾病,为临床诊断与治疗提供可靠参考,具有较高的临床诊断价值。

Objective To study the clinical diagnostic value of combined detection of TPOAb（anti-thyroid peroxidase antibody） and TGAb（thyroglobulin antibody） in the diagnosis of Hashimoto’s thyroiditis. Methods 85 cases of patients with Hashimoto’s thyroiditis admitted to our hospital from March 2016 to October 2017 were selected as the study group, and another 42 people with healthy examination were selected as the control group. The TPOAb and TGAb of both groups were detected. The sensitivity and specificity of single and combined detection were analyzed. Results The TPOAb and TGAb levels of the study group were significantly higher than those of the control group（P 〈0.05）. The sensitivity and specificity of TPOAb detection of the study group were 92.94% and 95.23% respectively, higher than 91.76% and 88.09% of TGAb detection. The sensitivity of combined detection of TPOAb and TGAb was significantly higher than single detection（P 〈0.05）. Conclusions The combined detection of TPOAb and TGAb can improve the diagnostic rate of Hashimoto’s thyroiditis, help to discover the disease as soon as possible, and provide reliable reference for clinical diagnosis and treatment, which has higher clinical diagnostic value.