甲状腺激素水平与老年患者冠状动脉病变严重程度的关系分析

Analysis on Relationship between Thyroid Hormone Levels and Severity of Coronary Artery Disease in Elderly Patients

目的分析甲状腺激素水平与老年患者冠状动脉病变严重程度的关系。方法选取我院2015年11月至2017年11月收治的86例且行冠状动脉造影的疑似冠心病患者,根据造影结果将其分为冠心病组(72例)和对照组(14例),冠心病组又分为单支病变组(54例)、双支病变组(13例)和多支病变组(5例)。测定其血清甲状腺激素、血脂水平,并比较Gensini评分。分析甲状腺激素水平与冠心病患者冠状动脉病变严重程度的关系。结果四组的LDL-C、TG、TSH、fT_4水平比较差异均无统计学意义(P>0.05)。与对照组比较,单支病变组、双支病变组和多支病变组的糖尿病史比例较高,fT_3水平较低,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,血清fT_3水平与冠状动脉病变Gensini积分存在负相关关系(P<0.05)。结论老年冠状动脉病变患者会出现fT_3水平下降的现象,应积极监测其fT_3水平,并及时进行处理。

Objective To analyze the relationship between thyroid hormone levels and severity of coronary artery disease in elderly patients. Methods 86 cases of patients suspected of coronary heart disease undergoing coronary angiography in our hospital from November 2015 to November 2017 were selected and divided into coronary heart disease group（72 cases） and control group（14 cases） according to the results of angiography. The coronary heart disease group was also divided into single branch lesion group（54 cases）, double branch lesions group（13 cases） and multibranch lesion group（5 cases）. The serum thyroid hormone and lipid levels were detected and the Gensini scores were compared. The relationship between thyroid hormone levels and severity of coronary artery disease in patients with coronary heart disease was analyzed. Results No statistical difference was found in the LDL-C, TG, TSH and fT4 levels between four groups（P 〉0.05）.Compared with the control group, the rates of diabetes history of the single branch lesion group, double branch lesions group and multibranch lesion group were higher, and the fT3 levels were lower（all P 〈0.05）. Pearson correlation analysis showed that the serum fT3 level had negative correlation with coronary artery lesion Gensini score（P 〈0.05）. Conclusions Elderly patients with coronary artery disease have the phenomenon of decreased fT3 levels, which should be actively monitored and timely processed.