转录因子Egr2/Egr3的生物学作用及与自身免疫性疾病的相关性

Study on Egr2/Egr3 and autoimmune diseases

早期生长反应因子Egr,属于即刻反应因子,其家族成员包括Egr1、Egr2、Egr3、Egr4。该家族主要参与调节细胞的生长、分化和凋亡等过程。现已发现,Egr2/Egr3不仅影响T/B细胞的增殖分化,也与多条信号通路如JAK/STAT、NF-κB等有交叉点。Egr2和Egr3与多种自身免疫性疾病的发生密切相关,如系统性红斑狼疮、硬皮病等。Egr2/Egr3有可能成为治疗自身免疫性疾病的新靶点。文章就Egr2/Egr3的生物学作用及与自身免疫性疾病相关性的研究进展进行综述。

Early growth response protein（ Egr） belongs to the immediate response factor,whose family members include Egr1,Egr2,Egr3 and Egr4. The Egr protein is mainly involved in the growth,differentiation and apoptosis of cells. It is reported the Egr2/Egr3 protein can not only effect the T/B cell＇s proliferation and differentiation,but also participate in multiple signaling pathways,such as JAK/STAT and NF-κB）. With the in-depth study,it is found that Egr2 and Egr3 have an indispensable relationship with the occurrence of various autoimmune diseases,including Systemic Lupus Erythematosus,Scleroderma,etc. Therefore,Egr2 and Egr3 may be a potential therapy target for autoimmune diseases. This paper reviews the biological effects of Egr2/Egr3 and its research progress in relation to autoimmune diseases.