肿瘤标志物CYFRA21-1、SCC、CEA、NSE、CA125检验在肺癌诊断中的价值

Diagnostic value of tumor markers CYFRA21-1,SCC,CEA,NSEand CA125 in lung cancer

目的:分析肿瘤标志物细胞角蛋白19片段(CYFRA21-1)、鳞状上皮细胞癌抗原(SCC)、癌胚抗原(CEA)、神经特异性烯醇化酶(NSE)以及糖类癌抗原125(CA125)检验在肺癌诊断中的临床应用价值。方法:将2015年11月至2016年11月于我院收治的74例肺癌患者(肺癌组)、74例肺良性肿瘤患者(良性肿瘤组)作为研究对象,同期选择74例到院体检的健康人群作为健康组。三组患者均在空腹状态下抽取4.0 ml静脉血,离心处理后进行实验室检验。对比三组患者中CYFRA21-1、SCC、CEA、NSE以及CA125水平的变化情况。结果:肺癌组的CYFRA21-1、SCC、CEA、NSE以及CA125水平均高于健康组和良性肿瘤组(P<0.05)。非小细胞肺癌患者的CYFRA21-1、SCC、CEA以及CA125水平均高于小细胞肺癌患者。小细胞肺癌患者的NSE水平显著高于非小细胞肺癌患者(P<0.05)。结论:肺癌患者的CYFRA21-1、SCC、CEA、NSE以及CA125水平将会显著增高,通过联合检测CYFRA21-1、SCC、CEA、NSE以及CA125能够在一定程度上提高肺癌疾病的诊断准确率,对于肺癌疾病的临床诊断和筛查具有十分重要的作用。

Objective：To analyze the clinical value of tumor markers cytokeratin 19 fragment（ CYFRA21-1）,squamous cell carcinoma antigen（ SCC）,carcinoembryonic antigen（ CEA）,neuron specific enolase（ NSE） and carbohydrate antigen 125（ CA125） in the diagnosis of lung cancer.Methods：There were 74 cases of patients with lung cancer from November 2015 to November 2016 in our hospital（ lung cancer group）,74 cases of lung benign tumor patients（ benign group） as the research object,and 74 cases of healthy people to the hospital as a health group.In the fasting state,4.0 ml venous blood was extracted in three groups of patients,after centrifugation laboratory test was did.The three groups of tumor marker levels in CYFRA21-1,SCC,CEA,NSE and CA125 were compared.Results：The levels of CYFRA21-1,SCC,CEA,NSE and CA125 in lung cancer group were significantly higher than those in healthy group and benign tumor group（ P〈0.05）.The levels of CYFRA21-1,SCC,CEA and CA125 in patients with non-small cell lung cancer were higher than those in patients with small cell lung cancer.The level of NSE in patients with small cell lung cancer was significantly higher than that in patients with non-small cell lung cancer（ P〈0.05）.Conclusion：CYFRA21-1,SCC,CEA,NSE and CA125 levels in lung cancer patients will be significantly increased.Combined detection of CYFRA21-1,SCC,CEA,NSE and CA125 to diagnose lung cancer in a certain extent,could improve the accuracy,which plays an important role in clinical diagnosis and screening of lung cancer.