术前雾化吸入对胸外科患者术后肺部并发症影响的Meta分析

Effects of Preoperative Aerosol Inhalation on Postoperative Pulmonary Complications in Patients Undergoing Thoracic Surgery:A Meta-analysis

目的评价术前雾化吸入对胸外科患者术后肺部并发症发生率的影响。方法 2017年1月,计算机检索万方数据库、维普中文期刊全文数据库、中国期刊全文数据库(China National Knowledge Infrastructure,CNKI)、中国生物医学文献数据库(China Biology Medicine disc,CBMdisc)、PubMed、Web of Science、Cochrane Library等数据库,查找关于术前雾化吸入对胸外科患者术后肺部并发症影响的随机对照研究(randomized controlled trials,RCT),检索时限均从建库至2016年12月。纳入的参考文献由2名研究人员独立进行质量评价并提取资料,采用RevMan 5.3软件进行Meta分析。结果最终纳入9篇文献,共804例研究对象。Meta分析结果显示,术前雾化吸入可减少胸外科患者术后肺不张的发生率[RR=0.28,95%CI(0.15,0.51),P<0.01]、肺部感染的发生率[RR=0.25,95%CI(0.13,0.48),P<0.01]。结论术前雾化吸入能够降低胸外科手术患者术后肺不张等肺部并发症的发生率。

Objective To analyze the effects of preoperative aerosol inhalation on postoperative pulmonary complications in patients undergoing thoracic surgery.Methods We searched the Wangfang,VIP and Chinese national knowledge infrastructure database（CNKI）,Chinese biomedical medicine disc（CBMdisc）,PubMed,Web of Science,The Cochrane Library to collect randomized controlled trials（RCTs）related to preoperative aerosol inhalation on postoperative pulmonary complications in patients undergoing thoracic surgery from establishment to December 2016.Two reviewers independently assessed the methodological quality of included RCTs.RevMan 5.3 was used for meta-analysis of these eligible RCTs.Results Totally9 RCTs and 804 cases were included.Meta-analysis showed that there was statistical difference between the two groups in postoperativecomplications of atelectasis[RR=0.28,95%CI（0.15,0.51）,P〈0.01]and pulmonary infections[RR=0.25,95%CI（0.13,0.48）,P〈0.01].Conclusions The evidence suggests that preoperative aerosol inhalation can reduce the incidence of postoperative pulmonary complications of atelectasis and etc in patients undergoing thoracic surgery.