乙肝免疫球蛋白阻断乙肝母婴垂直传播的疗效及影响因素

The effect and influencing factors of hepatitis B immunoglobulin blocking the vertical transmission of mother and child of hepatitis B

目的:探讨乙肝免疫球蛋白阻断乙肝母婴垂直传播的疗效及影响因素。方法:选择接受乙肝免疫球蛋白注射的乙肝病毒感染产妇及所生新生儿信息为观察组,并将同时期未注射乙肝免疫球蛋白的42例婴儿作为对照组,比较两组临床资料。结果:产前母体是否按照程序接种、母体为大三阳和小三阳为显著的独立危险因素;截止至1.5岁时,观察组新生儿感染率明显低于对照组(P<0.05)。结论:乙肝免疫球蛋白阻断乙肝母婴垂直传播具有很好的疗效,根据影响免疫效果的因素,我们建议应该妥善对相关人群进行治疗并实施乙肝免疫球蛋白阻断。

Objective：To explore the effect and influencing factors of hepatitis B immunoglobulin blocking the vertical transmission of mother and child of hepatitis B.Methods：The information of puerperant with hepatitis B virus infection receiving hepatitis B immunoglobulin injection and newborn infants were selected as the observation group.42 infants who were not injected with hepatitis B immunoglobulin at the same time were as the control group.The clinical data of the two groups were compared.Results：With or without vaccinated by program of matrix in prenatal,Da San Yang and Xiao San Yang of matrix were significant independent risk factors.At the age of 1.5,the infection rate of the newborn in the observation group was significantly lower than that of the control group（P〈0.05）.Conclusion：Hepatitis B immunoglobulin had a good effect on blocking the vertical transmission of hepatitis B of mother and baby.According to the factors that affect the immune effect,we suggested that the related people should be treated properly and hepatitis B immunoglobulin blockage should be implemented.