西黄胶囊联合放疗治疗老年宫颈癌

Therapeutic Effects of Xihuang Capsule Combined with Radiotherapy on Gerontal Patients with Cervical Carcinoma

目的:观察西黄胶囊联合调强适形放疗(IMRT)及后装治疗老年宫颈癌的临床疗效。方法:42例老年宫颈癌患者按照随机数字表法随机分为2组,对照组行盆腔调强适形放疗及后装治疗,实验组在对照组基础上口服西黄胶囊(1.5 g/次,2次/日)。所有入组患者治疗前、治疗后1个月行妇检、腹盆腔彩超及盆腔MRI检查以观察肿瘤近期疗效,并按照中医肿瘤症状分级量化标准进行症状分级,以评价两种治疗方法对患者生存质量的影响;于治疗前及治疗结束后1周分别检测患者血液中T淋巴细胞、NK细胞亚群、IL-6水平等免疫指标。结果:实验组和对照组的肿瘤治疗有效率分别为95.24%和90.48%(P>0.05);治疗结束后1周实验组患者外周血CD3^+、CD3^+CD4^+、CD3^+CD8^+及NK细胞(CD3^-CD56^+)水平明显高于对照组(P<0.05),而IL-6水平则明显低于对照组(P<0.05);治疗结束后1周实验组患者外周血中CD3^+T细胞、CD3^+CD4^+T细胞及IL-6水平较治疗前升高(P<0.05);对照组患者外周血中CD3^+T细胞及CD3^+CD8^+T细胞比例较治疗前下降(P<0.05),而IL-6水平较治疗前升高(P<0.05);实验组患者的盗汗、失眠、神疲乏力、头晕目眩、腰膝酸软等症状明显轻于对照组(P<0.05)。结论:与单纯调强适形放射治疗及腔内后装治疗老年宫颈癌患者相比,联合西黄胶囊组能提高患者免疫功能,降低不良反应。

Objective To investigate the curative effect of Xihuang Capsules combined with intensity-modulated radiation therapy （IMRT） and intracavitary brachytherapy against gerontal patients with cervical carcinoma. Methods Forty-two eld- erly patients with cervical cancer were randomly divided into two groups according to the random number table method. The control group received whole pelvic IMRT and intracavitary brachytherapy. The experimental group was given additional Xi- huang capsule （ 1.5 g b.i.d）. All patients received maternal examination, abdominal ultrasonography and pelvic MRI exami- nation before treatment and one month after treatment to observe the short-term efficacy of the tumor. In order to evaluate the effect of two treatments on the quality of life of the patients, the symptom classification was carried out according to the classification and quantification of the TCM （Traditional Chinese Medicine） symptoms. The immune indexes such as T lym- phocyte, NK cell subgroup and IL-6 level were measured before treatment and 1 week after treatment. Results The effec- tive rates of tumor treatment in experimental group and control group were 95.24% and 90.48% （P〉0.05） respectively. The levels of CD3＋ T cells, CD3＋CD4＋T cells, CD3＋CD8＋ T cells and CD3-CD56＋ NK cells of peripheral blood in the experi- mental group were significantly higher than those of the control group one week after the treatment （P〈0.05）, while the IL -6 level was significantly lower in the experimental group than that in control group （P〈0.05）. At one week after the end of treatment, the levels of CD3＋ T cells, CD3＋CD4＋ T cells and IL-6 in the peripheral blood of the experimental group were significantly higher than those before treatment （P〈0.05）. The proportion of CD3＋ T cells and CD3＋ CD8＋ T cells in the peripheral blood of the control group was significantly lower than that before treatment （P〈0.05）, while the level of IL -6 in the control group was higher than that before treatment （P〈0.05）. In the experimental group, the symptoms such as night sweats, insomnia, Shenpi fatigue, dizziness, weakness of waist and knees were significantly lower than those in the