经鼻塞式持续气道正压通气治疗新生儿呼吸窘迫综合征患儿的效果分析

Effect of nasal continuous positive airway pressure on infants with respiratory distress syndrome

目的探讨经鼻塞式持续气道正压通气治疗新生儿呼吸窘迫综合征患儿的效果。方法对佛山市妇幼保健院2016年9月-2017年9月间70例新生儿呼吸窘迫综合征患儿进行研究,根据通气方式分为鼻塞组(n=35)和传统组(n=35),鼻塞组进行经鼻塞式持续气道正压通气治疗,传统组进行鼻导管或面罩吸氧,分析总结两种通气方式的运用效果。结果鼻塞组患儿治疗24 h后Pa O2(73.8±6.7)mm Hg、p H(7.3±0.1)与传统组(64.2±7.8)mm Hg、(7.2±0.1)相比显著升高,Pa CO2水平(44.8±5.8)mm Hg与传统组(49.5±6.2)mm Hg相比显著降低(P=0.000、0.002、0.000)。鼻塞组患儿通气时间(25.3±5.1)h、住院时间(22.1±4.2)d、住院费用(2.1±1.4)元与传统组(31.2±5.6)h、(28.5±4.6)d、(2.8±1.1)元相比显著降低(P=0.000、0.000、0.023)。鼻塞组患儿并发症发生率8.6%与传统组31.4%相比显著降低(P=0.017),差异具有统计学意义。结论经鼻塞式持续气道正压通气治疗新生儿呼吸窘迫综合征,效果显著。

Objective To explore the effect of nasal continuous positive airway pressure on infants with respiratory distress syndrome. Methods Seventy neonates with respiratory distress syndrome were studied from September 2016 to September 2017.According to the ventilation method,they were divided into test group（ n = 35） and conventional group（ n = 35）. The test group received nasal continuous positive airway pressure therapy and the traditional group received nasal cannula or mask oxygen. The ventilation effects of the two groups were analyzed and summarized. Results Pa O2（ 73. 8 ± 6. 7） mm Hg and p H（ 7. 3 ± 0. 1） of the test group were significantly higher than those of the conventional group at 24 h after treatment,and the Pa CO2 level（ 44. 8 ± 5. 8）mm Hg was significantly lower than that of the conventional group（ 49. 5 ± 6. 2） mm Hg（ P = 0. 000,0. 002 and 0. 000）. Ventilation time（ 25. 3 ± 5. 1） h,hospitalization time（ 22. 1 ± 4. 2） d and hospitalization cost（ 2. 1 ± 1. 4） yuan in the test group were significantly lower than those in the traditional group（ 31. 2 ± 5. 6） h,（ 28. 5 ± 4. 6） d and（ 2. 8 ± 1. 1） yuan（ P = 0. 000,0. 000 and 0. 023）. The incidence of complications in the test group was significantly lower than that of the traditional group（ 8. 6% vs 31. 4%,P = 0. 017）.Conclusion The therapy effect of nasal continuous positive airway pressure in neonatal respiratory distress syndrome patients is good.