格拉斯哥预后评分对腹腔镜胃结直肠癌根治术近期临床结局的预测意义

Prognostic significance of Glasgow prognostic score for laparoscopic radical resection in gastric and colorectal cancer

目的:研究格拉斯哥预后评分(Glasgow prognostic score,GPS)对腹腔镜胃结直肠癌根治术后近期临床结局的预测意义。方法:回顾分析2014年6月至2016年3月接受腹腔镜胃结直肠癌根治术的226例患者的临床资料,根据术前外周血C反应蛋白(C reactive protein,CRP)、血清白蛋白(albumin,ALB)水平将患者分为3组,GPS 0组(CRP≤10 mg/L且ALB≥35 g/L)、GPS 1组(CRP>10 mg/L或白蛋白<35 g/L)与GPS 2组(CRP>10 mg/L且白蛋白<35 g/L),对比分析3组患者的临床资料、术后并发症及近期生存情况。结果:3组患者年龄、术前合并慢性病、肿瘤标志物、肿瘤TNM分期差异有统计学意义(P<0.05),性别、肿瘤部位、体质指数差异无统计学意义(P>0.05)。3组患者术后并发症发生率、术后近期生存曲线差异有统计学意义(P<0.05)。结论:GPS可作为预测腹腔镜胃结直肠癌根治性手术的预后参考指标,GPS评分高的患者预后可能较差。

Objective：To investigate the prognostic significance of the Glasgow prognostic score（GPS） in gastric and colorectal cancer patients who underwent laparoscopic radical resection. Methods：The clinical data of 226 gastric or colorectal cancer patients who underwent laparoscopic radical surgery in Second People＇s Hospital of Liaocheng from Jun. 2014 to Mar. 2016 were retrospectively analyzed. All patients were divided into 3 groups according to the preoperative level of serum C reactive protein（ CRP） and serum albumin（ ALB） ：GPS0 group（ CRP≤10 mg/L and ALB≥35 g/L）,GPS1 group（ CRP 〉10 mg/L or ALB 〈35 g/L） and GPS2 group（CRP 〉10 mg/L and ALB〈 35 g/L）. The general clinical data,postoperative complications as well as the recent survival were compared among the three groups. Results：The general data among the three groups：age,preoperative chronic diseases,tumor markers and tumor TNM stage were statistically significantly different（ P〈0. 05）. There were no significant differences in gender,tumor location and body mass index among the three groups（ P〈0. 05）. The differences of postoperative complication incidence and the short-term survival curve among the three groups were statistically significant（ P〈0. 05）. Conclusions：GPS can be used as a prognostic indicator for patients who underwent laparoscopic radical resection of gastric or colorectal cancer. Patients with a high GPS score may have a poor prognosis.