门脉高压症合并脾功能亢进行脾切除术后免疫功能的变化探讨

The Changes of Immune Function in Portal Hypertension and Hypersplenism Patients underwent Splenectomy

目的观察门脉高压症合并脾功能亢进行脾切除术后免疫功能的变化。方法收集辽宁省金秋医院2016—2017年收治的门脉高压症合并脾功能亢进患者37例，进行脾脏切除术。比较治疗前、术后第7天和第14天的细胞免疫及体液免疫水平变化。结果细胞免疫：患者术后CD3^＋、CD3^＋CD4^＋、CD3^＋CD8^＋、CD3^-CD16^＋CD56^＋细胞亚群比例逐渐增加，不同时间点差异有统计学意义（P〈0．05）。体液免疫：患者术后IgG、IgM、C4分子水平逐渐增加，不同时间点差异有统计学意义（P〈0．05）。结论门脉高压合并脾功能亢进患者行脾切除术后，可明显改善患者的细胞免疫和体液免疫水平。

Objective To observe the changes of postoperative immune function in patients with portal hypertension and hypersplenism underwent splenectomy. Methods A total of 37 patients with portal hypertension and hypersplenism were collected from Jinqiu Hospital from 2016 to 2017, and all patients underwent splenectomy. The cellular immune and humoral immune levels were compared before operation, postoperative No.7 days and 14 days. Results The results of cellular immunity indicated that the CD3^＋, CD3^＋CD4^＋, CD3^＋CD8^＋, and CD3^-CD16^＋CD56^＋ cell subgroup were increased gradually at different time points （P〈0.05）. The humoral immunity showed that IgG, IgM and C4 level were increased gradually at different time points （P〈0.05）. Conclusion The splenectomy could improve the cellular and humoral immune function in patients with portal hypertension complicated with hypersplenism.