氟西汀联用利培酮对精神分裂症患者焦虑、抑郁状态的影响

The impact of fluoxetine combined with risperidone on schizophrenia patients with anxiety and depression symptoms

目的探讨氟西汀联用利培酮对精神分裂症患者焦虑、抑郁状态的影响。方法回顾性分析2014年5月~2016年4月于本科室收治精神分裂症100例,将其分为联合组和单一组,各50例。单一组给予氟西汀(20mg/次,1次/d)及安慰剂治疗,联合组给予氟西汀(20mg/次,1次/d)加用利培酮(4mg/次,1次/d)治疗,均治疗12周。采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评价患者焦虑抑郁状态。统计分析患者疗效、HAMD及HAMA评分及不良反应发生情况,并进行组间对比。结果联合组患者治疗有效率显著高于单一组(P<0.05)。治疗前两组患者HAMD、HAMA评分无明显差异(P>0.05),治疗后两组患者的HAMD、HAMA评分均低于治疗前(P<0.05),且联合组治疗4周、12周的HAMD、HAMA评分均显著低于单一组(P<0.05)。联合组患者不良反应总发生率与单一组差异无统计学意义(P>0.05)。结论氟西汀联用利培酮能有效改善精神分裂症患者的焦虑、抑郁情绪,安全可靠,值得临床进一步推广应用。

Objective To observe the effect of fluoxetine combined with risperidone in the treatment of schizophrenia patients with anxiety and depression symptoms. Methods 100 schizophrenia patients who were admitted in our hospital from May 2014 to April 2016 were retrospectively analyzed. All the patients were randomised into the experimental group （ n=50 ） and the control group （ n=50 ） . The control group were given fluoxetine （ 20mg once daily ） and placebo, while the experimental group were given fluoxetine （ 20mg once daily ） and risperidone （ up to 4mg once daily ） . The treatment for the two groups continued for a period of 12 weeks. Hamilton Depression Rating Scale （HAMD） and Hamilton Anxiety Rating Scale （HAMA） were used to evaluate patients＇ anxiety and depression symptoms. Patients＇ HAMD and HAMA scores, curative effect, and adverse reaction rate were analysed and compared between groups. Results The experimental group showed statistically higher curative effect than the control group after treatment （P〈0.05） . The two groups showed no significant difference in HAMD and HAMA scores before treatment （ P〉0.05 ） and showed significantly lower scores after treatment （ P〈0.05 ） . Besides, the experimental group had significantly lower HAMD and HAMA scores than the control group after receiving treatment for 4 and 12 weeks （P 〈 0.05 ） . Both groups exhibited low incidence of adverse reaction, and there was no significant difference （P 〉 0.05 ） . Conclusion Fluoxetine combined with risperidone can effectively improve the curative effect in the treatment of schizophrenia patients with anxiety, depression symptoms. With high safety and reliability, it is worthy of further promotion in clinical situations.