多索茶碱联合持续正压通气治疗对合并精神障碍的OSAHS患者的疗效

Effect of doxofylline combined with continuous positive airway pressure on patients with OSAHS complicated with mental disorder

目的探究多索茶碱联合持续正压通气(CPAP)治疗对合并精神障碍的阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的临床疗效。方法选取为2014.1~2017.2之间我院收治的合并精神障碍的OSAHS患者74例,随机分为联合组和对照组,各37例。对照组患者单纯采用CPAP治疗,联合组患者则在CPAP治疗基础上给予多索茶碱,两组治疗时间均为4周,对比两组患者治疗前后的多导睡眠监测系统参数变化情况,并采用匹兹堡睡眠质量指数(PSQI)评价两组患者治疗前后的睡眠质量改善情况。结果治疗前两组患者的多导睡眠监测系统各项参数对比均无显著差异(P>0.05),治疗后两组患者上述指标均改善,且联合组的改善程度均显著优于对照组(P<0.05);治疗前两组患者的PSQI评分组间无显著差异(P>0.05),治疗后两组患者PSQI评分均降低,且联合组评分显著低于对照组(P<0.05)。结论联合应用多索茶碱及CPAP治疗可更有效的改善合并精神障碍的OSAHS患者的睡眠和呼吸状况,从而使患者更好地配合完成治疗及保证治疗效果。

Objective To investigate the clinical effect of doxofylline combined with continuous positive airway pressure （CPAP） on patients with obstructive sleep apnea hypopnea syndrome （OSAHS） complicated with mental disorder. Methods A total of 74 patients with OSAHS complicated with mental disorder were enrolled in our hospital from January 2014 to to February 2017. The patients were randomly divided into two groups： the combined group and the control group. The patients in the control group were treated with CPAP alone. The patients in the combined group were treated with doxofylline and CPAP together. The treatment time of the two groups was 4 weeks. Two groups were compared before and after treatment by the change of polysomnography monitoring system parameters and Pittsburgh Sleep Quality Index （PSQI） to evaluate the improvement of sleep quality. Results There was no significant difference in the parameters of the polysomnographybetween the two groups before treatment （ P 〉 0.05 ） . After treatment, the parameters mentioned above in both groups were improved, and the improvement of the combined group was better than that of the control group （P〈0.05） . There was no significant difference in the scores of PSQI between the two groups before treatment （P 〉 0.05 ）. After treatment, the PSQI scores mentioned above in both groups were decreased, and the PSQI scors of the combined group was lower than that of the control group （P 〈 0.05 ） . Conclusion The combined application of doxofylline and CPAP treatment can effectively improve the sleep and breath status of OSAHS patients with mental disorders, so that patients can better cooperate with the treatment and ensure the effect of treatment.