梅毒血清固定机制的研究进展

Advances in mechanism of syphilis serofast

经正规驱梅治疗后,梅毒血清固定患者血清反应素滴度可长期呈低滴度不下降。血清固定的发生主要与梅毒分期、血清初始滴度、无症状神经梅毒、苍白螺旋体(Treponema palladium,TP)重复基因型分型和细胞免疫抑制等因素有关。目前梅毒血清固定的机制不明,研究提示,梅毒血清固定与机体的免疫失衡和免疫抑制有关。从调节性T细胞(regulatory T cells,Tregs)/Th17细胞平衡异常、Toll样受体表达异常、Th1/Th2型细胞因子的失衡、T细胞亚群比例失调及microRNA表达谱的改变等方面,对梅毒血清固定机制的研究进展作一综述。

After standard treatment,the rapid plasma region titers of the patients suffered from syphilis with serofast can be long-term low titer. The occurrence of the serofast is mainly associated with syphilis staging,serum initial titer,asymptomatic neurosyphilis; TP repeat genotyping,cellular immunosuppression and other factors. Currently,the mechanism of serofast is still unclear. and which is believed to be related to unbalance of immune system and immuno-suppression. This article will discuss on different aspects related to serofast mechanism,including the abnormal balance of Tregs/Th17 cells,the abnormal Toll-like receptor expression,the unbalance of Th1/Th2 cytokines,the unbalance of T cell subsets and the change of microRNA expression profile.