癫表观遗传学研究进展

Research progress of epigenetics in epilepsy

癫是临床最常见的神经系统疾病,临床表现和病因多样,受遗传因素和环境因素的共同影响。传统遗传学机制不能完全解释癫的发生机制,因此环境因素影响基因表达可能成为癫发生机制研究的新方向。表观遗传学是研究环境因素或其他非DNA序列改变对基因表达的影响。本文拟对癫表观遗传学研究进展进行简要概述,以为癫发生机制和治疗提供新的视角。

Epilepsy is one of the most common neurological disorders with complex manifestations and etiologies. It is widely influenced by hereditary and environmental elements. Traditional genetic mechanism can not well explain the reason that epilepsy occurs. Therefore, epigeneties, which explores the effects of environment or non DNA sequential changes on gene expression, may provide a new perspective to unravel the underlying cause. This article intends to discuss recent research progress of epigenetics, which is likely to provide a new perspective to explain why epilepsy occurs and how to treat epilepsy in clinical practice.