血清脂肪酸谱与老年认知功能障碍的相关性研究

Analysis of correlation between serum fatty acid profile and cognitive impairment in the elderly

目的探讨血清脂肪酸谱与老年认知障碍的关系.方法于2015年在石家庄3个社区招募60岁以上老年人,进行基本情况问卷调查,采用蒙特利尔认知评估量表评估认知功能水平,检测血清生化指标,并分析血清脂肪酸谱.最终有效样本量为529名.采用多因素有序logistic回归模型分析脂肪酸谱与认知障碍的关系.结果认知功能正常、轻度认知障碍、中度认知障碍者分别占41.2％（218名）、51.4％（272例）、7.4％（39例）.调整年龄、性别、教育程度、总胆固醇、甘油三酯、HDL-C、LDL-C后,二十烯酸、神经酸及n-3多不饱和脂肪酸与n-6多不饱和脂肪酸的比值（n-3/n-6）与老年人认知受损风险OR（95％CI）值分别为1.06（1.02～1.10）、0.94（0.91～0.97）及0.17（0.04～0.73）.结论老年人认知受损风险随血清神经酸及n-3/n-6的升高而降低,并随二十烯酸水平升高而上升.

Objective To explore the relationship between cognitive impairment and serum fatty acid profile. Methods Participants aged ≥60 years were selected from 3 communities in Shijiazhuang in 2015. The questionnaire was performed to collect basic information. And Montreal Cognitive Assessment was applied for the evaluation of cognitive impairment. Blood lipid parameters and serum fatty acid profiles were analyzed for all the subjects. A total of 529 subjects were finally included in this research. Multivariate ordinal logistic model was used to analyze the relationship between serum fatty acid profile and cognitive impairment. Results Normal, mild and moderate cognitive impairment accounted for 41.2% （n=218）, 51.4%（n=272） and 7.4%（n=39） of all the subjects respectively. With control of age, gender, education, total cholesterol （TC）, total triglyceride （TG）, low density lipoprotein cholesterol （LDL-C）, and high density lipoprotein cholesterol （HDL-C）, the OR （95%CI） of eicosenoic acid, nervonic acid and ratio of n-3 and n-6 polyunsaturated fatty acid （n-3/n-6） was 1.06 （1.01-1.10）, 0.93 （0.91-0.96）, and 0.17 （0.04-0.73）. Conclusion The risk of cognitive impairment decreased with the raise of serum nervonic acid concentration and n-3/n-6, and increased with the raise of serum eicosenoic acid concentration.