牙髓再生的研究现状与发展前景

State of the art and perspective of pulp regeneration

近年来，牙髓血运重建、干细胞移植以及细胞归巢均在牙髓再生领域取得了阶段性进展。这些新技术分别从干细胞动员、募集、定向分化、干细胞亚群筛选、扩增与再植、生物材料的改性与优化以及生物活性因子的协同作用等方面深入研究和不断改进，旨在实现临床转化，提高牙髓再生的成功率，保存患牙。本文重点介绍牙髓血运重建的临床应用进展、干细胞移植和细胞归巢技术在牙髓再生方面的研究现状，以及未来临床转化所面临的挑战和策略。

Recently, various levels of success have been achieved in dental pulp and dentin regeneration using latest techniques such as pulp revaseularization, stem cell transplantation and cell homing. These cutting-edge technologies utilize stem cell mobilization, homing and directional differentiation, stem cell sub-population isolation, expansion and transplantation, modification and optimization of biomaterials and/or synergetie effects of biological cues. The objective of this review is to identify approaches for clinical translation and improve the success rates of pulp regeneration. We will focus on either basic and clinical research progress of dental pulp revascularization, or translational challenges and strategies of stein cell transplantation and cell homing in dental pulp regeneration.