槲皮素纳米载药系统的研究与应用

Research and application of quercetin-loaded nano drug delivery system

槲皮素具有多种生物活性和药理作用,但因水溶性小、生物利用度低、化学稳定性差等缺点限制了其临床应用。为了克服槲皮素的这些缺点,在临床上更好地发挥疗效,近年来已有多种新型给药系统在研究开发中,其中纳米载药系统成为研究的热点。纳米载药系统包括纳米粒、纳米囊、纳米脂质体、纳米胶束、纳米混悬剂及纳米乳等,具有减小粒径、增大表面积、增加药物透膜能力、改善药物的体内循环和分布、提高药物靶向性等优点。该文将近几年国内外对槲皮素纳米载药系统在增加溶解度和溶出度、提高生物利用度、增加药物稳定性、延缓药物释放、增加皮肤渗透性、增强抗氧化能力以及提高治疗作用等方面的研究与应用进行归纳总结,以期为槲皮素制剂的深入研究提供参考。

Quercetin has a variety of biological activities and pharmacological effects,but its clinical application is limited due to its low water solubility,low bioavailability and poor chemical stability. In order to overcome the above shortcomings of quercetin and achieve better clinical efficacy,many new drug delivery systems have been studied and developed in recent years,of which nano drug delivery system has become a research hotspot. Nano drug delivery system includes nanoparticles,nanocapsules,nanoliposomes,nanomicelles,nanosuspensions and nanoemulsions,with the advantages of reducing particle size,enlarging surface area,increasing drug permeability,improving intracorporeal circulation and distribution of the drug,enhancing drug targeting and so on. This article reviewed the latest progress at home and abroad about the studies and application of quercetin in nano drug delivery system,such as increasing solubility and dissolution,elevating bioavailability,raising drug stability,delaying drug release,enhancing skin permeability,promoting antioxidant capacity and improving therapeutic effect,in the hope of providing references for further research of quercetin preparations.