天然药物防治镉中毒的现代研究进展

Recent research progress on natural medicines in treatment of cadmium toxicity

镉污染是一个严重危害人类健康的国际性环境问题。人体主要通过摄入受镉污染的水、食物引起蓄积。20世纪50年代,日本＂痛痛病＂事件使镉毒性受到广泛关注。此外,镉还可引起肝、肾、肺等器官的损伤。因此,镉中毒的治疗已经成为研究热点,研究者们竭力探索有效的药物以预防和治疗镉中毒。目前,治疗镉中毒的主要药物为螯合剂,但其存在一定的安全性与有效性的问题。天然药物具有来源广泛、安全性高、副作用低等诸多优点,可开发用以拮抗镉毒性。该文综述近年来天然药物治疗镉中毒及其作用机制等方面的研究进展,为其进一步开发和深入研究提供参考。

Cadmium contamination of environment is a subject of serious international concern. Bioaccumulation of cadmium occurs primarily through ingestion of contaminated water and food. Cadmium poisoning came into prominence with the ＂ itai-itai＂ disease event in Japan in the 1950 s. It could also cause damages to liver,kidney,lung and other organs. Thus,the treatment of cadmium poisoning has become a research hotspot. Researchers are trying their best to explore prophylactic and therapeutic medicines for prevention and treatment of cadmium-induced poisoning. So far,chelation therapy,the conventional treatment for heavy metal toxicity,is reported to have a number of safety and efficacy issues. Natural medicines have a variety of advantages such as extensive sources,high safety,less adverse reactions,and thus have great potentials in treating cadmium poisoning. In this review,the progress in the antagonistic effects of natural drugs in cadmium poisoning and their therapeutic mechanisms were summarized in order to provide certain references for the future development and in-depth study of antagonistic substances.