小鼠肠道菌群对外周免疫器官影响的研究进展

Research progress on influence of intestinal microflora on peripheral immune organs in mice

近年来研究发现肠道微生物群的存在不仅对机体必需营养物质的代谢非常重要,而且在机体免疫系统发育中也扮演了关键的角色。其中小鼠体内部分微生物群通过自然选择以及与宿主的共同进化,形成与宿主生理学不可分割的宿主-微生物的共生关系,这些共生菌群通过参与先天和适应性免疫及多种监管机制的发育和维持,共同影响了机体免疫系统的形成。肠道中微生物的生态系统一旦被破坏,便会导致多种疾病特别是免疫系统相关疾病的发生。而外周免疫器官作为机体成熟免疫细胞活化、增殖、分化及定居的场所,时刻接纳着大量经抗原刺激活化后的免疫细胞定植,故肠道菌群的存在及改变对免疫细胞功能的维持发挥着重要的作用,故本文将对小鼠相关肠道菌群对外周免疫器官功能的影响作进一步综述。

The study found that the presence of intestinal microbiota is not only important for the metabolism of essential nutrients in the body,but also plays a key role in the development of the body＇s immune system in recent years.Partial microbiota,through natural selection and co-evolution with the host,forms symbiotic relationships with host microbes that are inseparable from host physiology in mice.Symbiotic flora affects the formation of the body＇s immune system by affecting innate and adaptive immunity and the development of various regulatory mechanisms.The destruction of the microbial ecosystem in the intestine can lead to the occurrence of many diseases,especially those related to the immune system.Peripheral immune organs always receive a number of immune cells colonized by antigen stimulation.So,the intestinal flora plays an important role in maintaining the function of immune cells.This article will investigates the effects of mouse-related intestinal flora on peripheral immune organ function.