丙戊酸钠对精神分裂合并梅毒感染患者MOAS与PANSS评分的影响

Effects of sodium valproate on MOAS and PANSS scores in patients with schizophrenia complicated with syphilis infection

目的探讨阿立哌唑联合丙戊酸钠对精神分裂合并梅毒感染患者外显攻击行为量表(MOAS)、阳性和阴性症状量表(PANSS)评分的影响。方法选择医院2011年3月-2014年3月收治的精神分裂合并梅毒感染患者40例为研究对象,分为联合组和对照组,各20例,对照组患者采用阿立哌唑联合头孢曲松钠治疗,联合组患者采用阿立哌唑、头孢曲松钠联合丙戊酸钠治疗,比较两组患者MOAS评分、PANSS评分、临床治疗有效率、快速血浆反应素试验(RPR)转阴率、复发率等指标评估临床疗效。结果治疗2周、4周、6周,联合组患者阳性症状评分、阴性症状评分、一般精神病理评分较对照组降低(P<0.05);治疗2、4、6周联合组患者MOAS为(5.33±1.89)分、(3.90±1.35)分、(2.12±1.02)分低于对照组(P<0.05);联合组治愈+显效患者多于对照组,但两组治疗差异无统计学意义;两组患者RPR转阴、复发情况,差异均无统计学意义。结论对精神分裂合并梅毒感染患者,采用阿立哌唑联合丙戊酸钠治疗,有利于降低MOAS、PANSS评分,改善患者临床症状,具有一定的临床意义。

OBJECTIVE To study and analyze the effects of aripiprazole combined with sodium valproate on the modified Overt Aggression Scales（MOAS）and Positive and Negative Syndrome Scale（PANSS）scores in patients with schizophrenia complicated with syphilis infection.METHODS Forty patients with schizophrenia complicated with syphilis infection enrolled in our hospital from Mar.2011 to Mar.2014 were divided into combined group（n=20）and control group（n=20）.The patients in the control group were treated with aripiprazole and ceftriaxone sodiuma,and patients in the combined group were treated with aripiprazole,sodium valproate combined with ceftriaxone sodium.The clinical curative effect was evaluated by MOAS score,PANSS score,clinical treatment efficiency,rapid plasma reactivity test（RPR）negative rate,recurrence rate and other indicators.RESULTS After 2 weeks,4 weeks,and 6 weeks of treatment,the positive symptom score,negative symptom score and general psychopathology score of the combined group were significantly lower than those of the control group（P〈0.05）.The MOAS of the combined group after 2 weeks,4 weeks,and 6 weeks of treatment were（5.33±1.89）points,（3.90±1.35）points and（2.12±1.02）points,which were significantly lower than those of the control group（P〈0.05）.The number of patients with cured and effective effects in the combined group was more than that in the control group,but there was no significant difference in clinical treatment between the two groups.The differences of RPR negative rate and recurrence rate between the two groups were not significant.CONCLUSION Using aripiprazole combined with sodium valproate for the treatment of schizophrenia with syphilis infection,is conducive to reducing MOAS and PANSS scores,and improving the clinical symptoms of patients,which has a certain clinical significance.