幽门螺旋杆菌感染与原发性高血压患者靶器官功能损害相关性分析

Correlation between Helicobacter pylori infection and target organ dysfunction in patients with primary hypertension

目的探讨幽门螺旋杆菌感染与原发性高血压患者靶器官功能损害的相关性。方法回顾性分析2015年5月-2017年1月医院收治的原发性高血压患者100例,根据幽门螺旋杆菌感染情况分为感染组42例和未感染组58例,同期选择医院健康查体的正常人群100名。观察原发性高血压患者和健康体检者幽门螺旋杆菌感染率差异。观察两组患者的靶器官功能损害情况。结果原发性高血压患者幽门螺旋杆菌感染率为42.00%(42/100)高于健康体检者18.00%(18/100)(P<0.001);感染组颈动脉内膜中膜厚度增厚、超敏C-反应蛋白(hs-CRP)、总胆固醇、甘油三脂、低密度脂蛋白分别为(1.08±0.14)mm、(6.17±2.01)mg/L、(6.61±1.76)mmol/L、(2.34±0.71)mmol/L、(3.44±0.72)mmol/L均高于未感染组(P<0.05);而射血分数及高密度脂蛋白分别为(56.37±9.81)%及(1.06±0.18)mmol/L均低于未感染组(P<0.05)。结论原发性高血压患者幽门螺旋杆菌感染率较高,靶器官功能损伤加重,可能是通过促进脂质代谢紊乱和体内炎症反应导致。

OBJECTIVE To investigate the relationship between Helicobacter pylori infection and target organ dysfunction in patients with primary hypertension.METHODS A total of 100 cases of patients with primary hypertension in our hospital from May 2015 to Jan.2017 were retrospectively analyzed,and were divided into infection group（42 cases）and uninfected group（58 cases）according to H.pylori infection conditions.Another 100 healthy adults in our hospital for health examination during the same period were enrolled.The differences of H.pylori infection between patients with primary hypertension and healthy persons were observed,and the damages of target organs in two groups of patients were studied as well.RESULTS The rate of H.pylori infection in primary hypertension patients was 42.00%（42/100）,which was significantly higher than 18.00%in healthy subjects（18/100）（P〈0.001）.The thickness of intima membrane in the carotid artery,hypersensitive C-reactive protein（hs-CRP）,total cholesterol,triglyceride and low density lipoprotein in the infection group were（1.08±0.14）mm,（6.17±2.01）mg/L,（6.61±1.76）mmol/L,（2.34±0.71）mmol/L and（3.44±0.72）mmol/L,which were significantly higher than those in the uninfected group（P〈0.05）.However,the ejection fraction and high density lipoprotein were（56.37±9.81）% and（1.06±0.18）mmol/L,which were significantly lower than those of the uninfected group（P〈0.05）.CONCLUSIONThe infection rate of H.pylori is higher in patients with primary hypertension,and the aggravation of target organ function may be caused by promoting lipid metabolism and inflammatory reaction in vivo.