头孢西丁对直肠癌根治术患者切口感染的治疗效果

Effect of cefoxitin on incision infection in patients with radical resection of rectal cancer

目的探讨头孢西丁对直肠癌根治术患者切口感染的预防作用及效果。方法选取2011年3月-2016年9月医院治疗的原发直肠癌肿瘤患者207例,随机分为试验组104例,对照组103例。对照组术后采用常规护理及常规对症治疗,试验组在此基础上加用头孢西丁治疗。比较两组患者住院天数、抗菌药物应用天数,分别检测两组患者术前及术后第4、7、10天的体温、血浆白细胞数量、C-反应蛋白(CRP)、白细胞介素-2(IL-2)、IL-4、IL-6、IL-10及肿瘤坏死因子-α(TNF-α)、干扰素-γ(INF-γ)水平及并发症情况。结果试验组患者住院天数及抗菌药物应用天数分别为(7.58±0.88)、(3.74±0.48)天少于对照组(P<0.05);治疗后4、7、10天试验组患者体温、血浆白细胞数量、CRP、IL-2、IL-4、IL-6、IL-10、TNF-α及INF-γ与对照组比较差异有统计学意义(P<0.05),其中治疗后10天试验组患者体温、血浆白细胞数量、CRP、IL-2、IL-4、IL-6、IL-10、TNF-α及INF-γ分别为(36.73±0.40)℃、(9.76±1.07)×109/L、(3.48±0.49)mg/L、(3.19±0.39)、(4.38±0.56)、(10.09±1.12)、(8.21±0.91)、(81.29±10.21)及(12.53±1.46)μg/L均低于对照组(P<0.05);试验组发生并发症21例少于对照组56例(P<0.001)。结论头孢西丁对直肠癌根治术患者切口感染可起到预防作用,减低炎症因子,减少术后并发症,效果较好。

OBJECTIVE To investigate the preventive effect and efficacy of cefoxitin on incision infection in patients with radical resection of rectal cancer and the effect of interleukin group.METHODS A total of 207 cases of patients with primary rectal cancer from Mar.2011 to Sep.2016 in our hospital were selected and randomly divided into study group of 104 cases and control group of 103 cases.The control group was given routine therapy and routine nursing care after operation,and the study group was treated with cefoxitin therapy based on the control group.The length of hospital stay and days of antibiotic application between the two groups were compared.The body temperature,plasma leukocyte count,C-reactive protein,levels of IL-2,IL-4,IL-6,IL-10,TNF-αand INF-γwere compared before surgery and on the fourth,seventh,and tenth day after operation.RESULTS The hospitalization days and antibiotic use days in the study group were（7.58±0.88）d and（3.74±0.48）d,which were significantly lower than those in the control group（P〈0.05）,and levels of body temperature,plasma leukocyte count,CRP,IL-2,IL-4,IL-6,IL-10,TNF-αand INF-γon the fourth,seventh,and tenth day after operation between the study group and the control group had significant differences（P〈0.05）.Levels of body temperature,plasma leukocyte count,CRP,IL-2,IL-4,IL-6,IL-10,TNF-αand INF-γon the tenth day after operation of the study group were（36.73±0.40）℃,（9.76±1.07）×109/L,（3.48±0.49）mg/L,（3.19±0.39）,（4.38±0.56）,（10.09±1.12）,（8.21±0.91）,（81.29±10.21）,and（12.53±1.46）μg/L,which were significantly lower than those of the control group（P〈0.05）.There were 21 cases of complications in the study group,which were significantly less than 56 cases in the control group（P〈0.001）.CONCLUSIONCefoxitin can play a role in preventing incision infection in patients with rectal cancer,and can reduce inflammatory factors,,and reduce the postoperative complications,and the effect is better.