左室射血分数保留慢性心衰患者血同型半胱氨酸的表达水平研究

Homocysteine Levels in Ejection Fraction Preserved Heart Failure Patients

目的:高同型半胱氨酸(HCY)血症与心血管疾病密切相关。血清HCY水平与慢性心力衰竭(CHF)患者密切相关。我们拟评估左室射血分数(LVEF)保留的CHF患者中的HCY水平表达情况。方法:本研究共入选80例LVEF保留的CHD患者和40例基本临床信息匹配的对照患者。收集入选人群临床资料,并分析两组间的HCY表达差异。结果:CHF患者和对照组年龄分别为(61.2±11.5)岁和(59.1±11.2)岁,而LVEF分别为(58.2±5.1)%和(59.2±4.9)%,通过多元logostic回归分析显示LVEF保留心力衰竭患者中HCY水平与NT-pro BNP,hsCRP,E/A比率独立相关。结论:本研究结果提示高同型半胱氨酸血症在LVEF保留心力衰竭中表达水平升高。

Objective ： Increased homocysteine （HCY） levels are associated with an increased risk of cardiovascular disease. Plasma HCY is increased in chronic heart failure （CHF） patients. We aimed to evaluate the HCY levels in patients with diastolic heart failure with preserved left ventricular ejection fraction （LVEF）. The clinical data of two groups were collected and the difference HCY level was analyzed. Methods： 80 patients who were hospitalized for symptomatic heart failure with preserved LVEF, were studied as well as 40 age and sex matched healthy subjects who comprised the control group. Results： The mean age was （61.2± 11.5 ） years in the heart failure group and （59.1± 11.2 ） years in the control group. The mean LVEF was （58.2±5.1）% in the heart failure group and （59.2±4.9）% in the control group. Multiple regression analysis indicated that NT-proBNP, hs-CRP, E/A ratio were independently associated with hyperhomocysteinemia. Conclusion ： Hyperhomocysteinemia is prevalent in heart failure with preserved ejection fraction.