生大黄浸泡液保留灌肠联合加贝酯治疗重症急性胰腺炎随机平行对照研究

Randomized Controlled Study on the Treatment of Severe Acute Pancreatitis with Rhubarb Dipping Enema and Gabexate Intravenously

[目的]观察生大黄浸泡液灌肠保留联合加贝酯治疗重症急性胰腺炎疗效。[方法]使用随机平行对照方法,将56例住院患者按随机数字法随机分两组;抗菌素、平衡酸碱和电解质、禁食、禁饮、胃肠减压。对照组28例加贝酯300mg+5%葡萄糖500m L,1次/d,静滴;3d后加贝酯100mg+5%葡萄糖500m L,1次/d,静滴。治疗组28例生大黄100g+200m L开水浸泡,过滤,冷却至常温灌肠,保留30min,1次/d;加贝酯治疗同对照组。连续治疗7d为1疗程。观测临床症状、血白细胞、血淀粉酶、C反应蛋白、治愈时间、不良反应。治疗1疗程,判定疗效。[结果]血白细胞计数、血淀粉酶、C反应蛋白两组均有改善(P<0.05),治疗组改善优于对照组(P<0.05)。临床疗效两组无显著差异(P>0.05)。治愈时间治疗组短于对照组(P<0.05)。[结论]生大黄浸泡液保留灌肠联合加贝酯治疗重症急性胰腺炎,疗效满意,无严重不良反应,值得推广。

[Objective] To observe the curative effect of rhubarb dipping enema combined with gabexate intravenous drip in severe pancreatitis. [Method] Using randomized parallel control method,56 inpatients were randomly divided into two groups according to random number method. Antibiotics were used to balance acid-base and electrolytes,fasted and forbidden to drink. Control group,28 cases of gabexate 300 mg＋5% glucose 500 mL,1 times/d,intravenous infusion;3 d gabexate 100 mg＋5% glucose 500 mL,1 times/d,intravenous infusion. The treatment group,28 cases of rhubarb 100 g＋200 mL soaked in water,the filtrate removed,cooled to room temperature for enema treatment,1 time/d; Gabapeptide treatment with the control group. Continuous treatment 7 d for a course of treatment. Clinical symptoms,white blood cell count,blood amylase,c-reactive protein,cure time,and adverse reactions were observed. Treatment of a course of treatment to determine the efficacy. [Results] The blood white cell count,blood amylase and C-reactive protein in treatment group were better than those in control group（P〈0.05）. There was no significant difference in clinical efficacy between the two groups（P〈0.05）. The cure time in the treatment group was lower than that in the control group（P〈0.05）. [Conclusion] Rhubarb soaking liquid enema combined with gabexate intravenous drip treatment of severe pancreatitis,with satisfactory results,no serious adverse reactions,it is worth promoting.