强迫性障碍患者厌恶加工的性别差异

Gender differences in disgust processing in patients with obsessive-compulsive disorder

目的探讨强迫性障碍患者厌恶加工的性别差异。方法采用帕多瓦量表（Paduain—ventory—Washington State University revision，PI-WSUR）、耶鲁布朗强迫量表（Yale—Browno bsessive-com-pulsive scale，Y-BOCS）和词汇判断任务对74例强迫性障碍患者（男39例，女35例）和65例健康对照者（男35例，女30例）评估其强迫症状及严重程度，并记录包括核心厌恶词、道德厌恶词和中性词的正确率、反应时以及厌恶评级，分析强迫性障碍患者组以及对照组厌恶加工的性别差异。结果强迫性障碍组男性与女性在核心厌恶词[（753．6±84．1）ms，（711．8±83．8）ms]、道德厌恶词[（813．5±89．0）ms，（749．4±81．4）ms]以及中性同[（775．3±91．8）ms，（725．9±104．2）ms]的反应时差异均具有统计学意义（P〈0．05或P〈0．01），正确率及厌恶评级上均差异无统计学意义。对照组仅在中性词反应时比较中男性比女性长[（712．7±95．7）ms，（658．8±64．0）ms]，差异具有统计学意义（P〈0．01）。Pearson相关分析显示男性与女性均具有核心厌恶词反应时与PI—WSUR总分的负相关（P〈0．05），OCD患者PI—WSUR、Y—BOCS与厌恶加工的相关变量存在性别差异。结论强迫性障碍患者厌恶加工存在性别差异，强迫性障碍患者女性的核心厌恶和道德厌恶均高于男性，女性强迫性障碍患者具有特殊的高道德厌恶感。

Objective To explore the gender differences in disgust processing in patients with obsessive-compulsive disorder （OCD）. Methods A total of 74 patients with obsessive-compulsive disorder （39 males and 35 females） and 65 uormal healthy controls （35 males and 30 females ） were assessed with Padua inventory-Washington State University revision （P1-WSUR）, Yale-Brown obsessive-compulsive scale （Y-BOCS） and were tested the lexieal decision task,in order to evaluale their OCD symptoms and severity. The results of reaction time, accuracy and rating intensity of core disgust words,moral disgust words and neutral words were recorded, and the gender differences ia disgust processing in patients with obsessive-compulsive disorder and normal healthy controls were analyzed. Results The reaction time of core disgust words （ （ 753.6±84.1 ） vs （ 711.8±83.8） ms） , the reaction time of moral disgust words（ （813.5±89.0） vs （ 749.4± 81.4） ms） and neutral words（ （775.3±91.8） vs （725.9± 104.2） ms） showed significant differences between males and females in pateints with OCD, but there were no differences in accuracy and rating intensity （P〈 0.05 or P〈0.01 ）, In normal healthy controls ,there were only differences between males and females in reaction time of neutral words ,females were also showed shorter reaction time than males （P〈0.01）. Pearson correlation analysis showed thal both male and female patients had a negative correlation between the reaction time of core disgust words and total PI-WSUR scores （P〈0.05）. There was a gender difference in the relative variables of PI-WSUR, Y-BOCS and disgust processing in OCD patients. Conclusion There were gender differences in disgust cognitive processing in patients with obsessive-compulsive disorder, females with obsessive-compulsive disorder have higher core disgust and moral disgust than males. Females with OCD have a special high sense of moral disgust.