慢性自发性荨麻疹患者血清胃泌素释放肽水平与疾病活动度及瘙痒的关系

Association of serum gastrin-releasing peptide levels with disease activity and pruritus in patients with chronic spontaneous urticaria

目的 探讨慢性自发性荨麻疹（CSU）患者血清胃泌素释放肽（GRP）水平与疾病活动度、瘙痒程度的相关性。方法 收集2016年6 - 12月就诊于山西医科大学第一医院皮肤科门诊的61例CSU 患者和59例健康体检者外周血标本，根据慢性荨麻疹活动度1周评分（UAS7）和视觉模拟评分（VAS）分别评估患者的疾病活动度和瘙痒程度，采用酶联免疫吸附法检测患者与健康对照血清GRP含量，分析CSU患者GRP水平及其与疾病活动度及瘙痒程度的相关性。采用SPSS22.0软件对数据进行统计分析，计量资料比较采用Mann-Whitney U或Kruskal-Wallis检验。GRP与UAS7及VAS的相关性采用Spearman相关性分析。结果 CSU患者血清中GRP水平［M（P25 - P75）］为11.20 ng/L（7.31 - 22.23 ng/L），对照组GRP水平为7.74 ng/L（7.06 - 9.71 ng/L），两组差异有统计学意义（Z = 4.44，P 〈 0.001）；CSU患者GRP水平与UAS7呈正相关（r = 0.36，P = 0.004），与VAS呈正相关（r = 0.34，P = 0.007）。结论 CSU 患者外周血GRP水平升高，并与疾病活动度和瘙痒程度呈正相关。

Objective To evaluate the correlation of serum gastrin-releasing peptide （GRP） levels with disease activity and pruritus in patients with chronic spontaneous urticaria. Methods Totally, 61 patients with chronic spontaneous urticaria were enrolled from the Department of Dermatology of Frist Hospital of Shanxi Medical University between June 2016 and December 2016, and 59 health checkup examinees served as controls. Peripheral blood samples were collected from these patients and healthy controls. The urticaria activity score over 7 days （UAS7） and visual analogue scale （VAS） score was used to evaluate the disease activity and degree of pruritus respectively. Enzyme-linked immunosorbent assay （ELISA） was performed to detect the serum GRP levels in the patients and healthy controls. The correlations of serum GRP levels with disease activity and degree of pruritus were analyzed. Statistical analysis was carried out by Mann-Whitney U test or Kruskal-Wallis test and Spearman′s correlation analysis for evaluation of correlations of GRP levels with UAS7 and VAS scores using SPSS22.0 software. Results The serum GRP level was significantly higher in the patients with chronic spontaneous urticaria than in the healthy controls （M [P25 - P75]： 11.2 [7.31 - 22.23] ng/L vs. 7.74 [7.064 ± 9.71] ng/L, Z = 4.44, P 〈 0.001）. Among the patients with chronic spontaneous urticaria, the serum GRP level was positively correlated with the UAS7 score （r = 0.36, P = 0.004） and the VAS score （r = 0.34, P = 0.007）. Conclusion The GRP level in the peripheral blood was elevated in the patients with chronic spontaneous urticaria, and positively correlated with the disease activity and degree of pruritus.