氯吡格雷联合阿托伐他汀治疗脑梗死的临床研究

Clinical study of clopidogrel combined with atorvastatin in the treatment of cerebral infarction

目的探讨脑梗死患者采用氯吡格雷联合阿托伐他汀治疗的临床效果。方法选取佛山市顺德区大良医院2015年1月-2017年11月收治的100例脑梗死患者,随机将其分为对照组和观察组各50例,对照组采用常规对症治疗,观察组在此基础上给予氯吡格雷联合阿托伐他汀,比较两组患者的临床疗效、神经功能缺损评分、日常生活活动能力。结果观察组治疗后NIHSS评分为(3.4±1.4)分,Batherel指数为(60.7±12.4)分,优于对照组的(5.8±2.1)分和(51.5±10.8)分;观察组总有效率为94.0%,高于对照组的84.0%;差异均有统计学意义(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论氯吡格雷联合阿托伐他汀治疗脑梗死有助于促进神经功能恢复,提升生活能力及治疗效果,不良反应率低,值得临床推广。

Objective To discuss the effect of clopidogrel combined with atorvastatin in the treatment of cerebral infarction. Methods 100 patients with cerebral infarction treated in Shunde District Daliang Hospital of Foshan City from January 2015 to November 2017 were randomly divided into the control group and the observation group with 50 cases in each group. The patients in control group were treated with conventional symptomatic treatment, and the patients in observation group were given clopidogrel combined with atorvastatin on this basis. The clinical efficacy, neurological deficit score, activities of daily living were compared between the two groups. Results After treatment, the NIHSS score and the Batherel index of the observation group were（3.4±1.4） scores and（60.7±12.4） scores, which were significantly better than（5.8±2.1） scores and（51.5±10.8） scores of the control group; The total effective rate of the observation group was 94.0%, which was higher than 84.0% of the control group; The differences were statistically significant（P〈0.05）. There was no significant difference in the incidence of adverse reactions between the two groups（P〈0.05）. Conclusion Clopidogrel combined with atorvastatin in the treatment of cerebral infarction is helpful to promote the recovery of nerve function, improve the living ability and treatment effect, with low adverse reaction rate, is worthy of clinical promotion.