白细胞介素6:一种可预测心房颤动发生的风险因素

Interleukin 6: A predictable risk factor for the occurrence of atrial fibrillation

近年来,研究发现炎症在心房颤动(atrial fibrillation,AF)的发生、发展过程中起重要作用,并证实高血压、慢性肾病(chronic kidney disease,CKD)、冠心病、瓣膜病、心脏外科手术等均为AF发生的危险因素。炎性因子IL-6是预测AF发生的独立因素,且存在一定的遗传学证据。本文就IL-6与AF发病风险的相关性,进一步阐明炎性因子在AF发病机制中的作用,可为AF的发病风险评估提供新的生物标志物。

In recent years, studies have found that inflammation plays an important role in the occurrence and development of atrial fibrillation（AF）. Studies have confirmed that hypertension, chronic kidney disease, coronary heart disease, valvular disease, or cardiac surgeries are risk factors for the occurrence of AF. Moreover, inflammatory factor interleukin 6（IL-6） is an independent factor predicting the occurrence of AF, and there is a certain genetic evidence. In this paper, we summarize the correlation between IL-6 and the occurrence risk of AF, further clarifying the role of inflammatory factors in the pathogenesis of AF could provide new biomarker for the risk assessment of AF.