摘要
随着测序技术的成熟，梅毒螺旋体在世界各地被发现不同亚种，以双基因法或三基因法进行分型得到广泛认可。在推动梅毒分子流行病学发展的同时，螺旋体的毒力、血清固定现象、耐药性及发病部位等临床特点被发现与基因分型存在一定相关性，如14f/f的毒力可能更强，血清固定现象更容易发生在Tpr i基因菌株感染的患者，耐大环内脂类药的菌株可能与A2058、A2059基因相关等，本文将就此进行综述。
With the development of genome sequencing technology, Treponema pallidum has been found to have different subspecies all around the world.It is widely recognized that Treponema pallidum could be subtyped by analyzing two or three target genes.Advances in molecular epidemiology of syphilis reveal that clinical characteristics of Treponema pallidum, such as virulence, serofast, drug resistance and the site of infection, are related to its subspecies.Specifically, 14f/f may be more virulent; serofast may be more likely to happen in patients infected with Treponema pallidum of Tpr i genotype; A2058 and A2059 genes may be related to resistance to macrolides.All these will be summarized in this review.
作者
刘进权
许卜方
胡文龙
王千秋
Liu Jinquan;Xu Bufang;Hu Wenlong;Wang Qianqiu(Institute of Dermatology, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Nanjing 210042, China)
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2018年第6期468-471,共4页
Chinese Journal of Microbiology and Immunology
关键词
梅毒
基因分型
血清固定
耐药
Syphilis
Genotype
Serofast
Drug resistance
