EZH2在肝脏疾病中的研究进展

Role of EZH2 in liver disease

Zeste基因增强子同源物2(enhancer of zeste homolog2,EZH2)在一些恶性肿瘤组织中呈现过度表达,与肿瘤的生长、发展、预后有着密切的关系.最新研究表明,EZH2在肝脏疾病领域除了与肝癌的发生、进展相关,在免疫方面也发挥着不可忽视的作用,其参与许多肝脏疾病的发生、发展,与慢性乙型肝炎的病毒复制、非酒精性脂肪性肝病的炎性反应、慢性肝炎肝纤维化的进展均有着密切的关系,可能成为今后肝病研究领域的重要方向.本文就最近十年来对EZH2在肝脏疾病中的研究进展及其在治疗中的潜在应用价值进行综述.

Overexpression of enhancer of zeste homolog 2 （EZH2） protein has been found in several malignant tumor tissues and is closely related to the degree of tumor differentiation, clinical stage, tumor size, and prognosis. The latest research shows that overexpression of EZH2 is related not only with immunoregulation but also with the replication of hepatitis B virus, the occurrence of non-alcoholic fatty liver disease, and the progress of liver fibrosis, which may become an important subject in the field of liver disease research. This paper reviews the role of EZH2 in some liver diseases and its potential application in treatment of these diseases in recent ten years.